ArticleDiabetologia2006
Direct regulation of insulin secretion by angiotensin II in human islets of Langerhans.
Article in Diabetologia, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 50 citations in OpenAlex.
- Angiotensin ii therapy in refractory septic shock: which patient can benefit most? A narrative review.Journal of anesthesia, analgesia and critical care · 2024Review
- Insulin in the regulation of the renin-angiotensin system: a new perspective on the mechanism of insulin resistance and diabetic complications.Frontiers in endocrinology · 2024Article
- Alterations in mouse visceral adipose tissue mRNA expression of islet G-protein-coupled receptor ligands in obesity.Diabetic medicine : a journal of the British Diabetic Association · 2022Article
- Adipose Tissue Secretion Pattern Influences β-Cell Wellness in the Transition from Obesity to Type 2 Diabetes.International journal of molecular sciences · 2022Review
- Endoplasmic Reticulum (ER) Stress in Part Mediates Effects of Angiotensin II in Pancreatic Beta Cells.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Acute, local infusion of angiotensin II impairs microvascular and metabolic insulin sensitivity in skeletal muscle.Cardiovascular research · 2019Article
- The adhesion receptor GPR56 is activated by extracellular matrix collagen III to improve β-cell function.Cellular and molecular life sciences : CMLS · 2018Article
- Comparative effects of angiotensin II and angiotensin-(4-8) on blood pressure and ANP secretion in rats.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2017Article
- ACE2 deficiency reduces β-cell mass and impairs β-cell proliferation in obese C57BL/6 mice.American journal of physiology. Endocrinology and metabolism · 2015Article
- Activation of angiotensin type 2 receptors partially ameliorates streptozotocin-induced diabetes in male rats by islet protection.Endocrinology · 2014Article
- Angiotensin type 2 receptor in pancreatic islets of adult rats: a novel insulinotropic mediator.American journal of physiology. Endocrinology and metabolism · 2013Article
- Control of adipogenesis by the autocrine interplays between angiotensin 1-7/Mas receptor and angiotensin II/AT1 receptor signaling pathways.The Journal of biological chemistry · 2013Article
- Renin-angiotensin system revisited.Journal of internal medicine · 2008Review
- Vasopressin potentiates corticotropin-releasing hormone-induced insulin release from mouse pancreatic beta-cells.The Journal of endocrinology · 2008Article
- The physiology of a local renin-angiotensin system in the pancreas.The Journal of physiology · 2007Review
- Metabolic actions of angiotensin receptor antagonists: PPAR-gamma agonist actions or a class effect?Current opinion in pharmacology · 2007Review
- Metabolic effects of antihypertensive agents: role of sympathoadrenal and renin-angiotensin systems.Naunyn-Schmiedeberg's archives of pharmacology · 2006Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
aims/hypothesisThis study aimed to identify the expression of angiotensin II receptors in isolated human islets and beta cells and to examine the functional consequences of their activation. MATERIALS AND
methodsSingle-cell RT-PCR was used to identify whether human islet cells express mRNA for type 1 angiotensin II receptors (AT(1)), and western blotting was used to determine AT(1) protein expression by human islets and MIN6 beta cells. We measured changes in intracellular calcium by microfluorimetry using Fura 2-loaded MIN6 cells and human islet cells. Dynamic insulin secretory responses were determined by RIA following perifusion of human islets and MIN6 cells.
resultsHuman islets expressed mRNAs for both the angiotensin precursor, angiotensinogen, and for angiotensin-converting enzyme. In addition, human and mouse beta cells expressed AT(1). These were functionally coupled to increases in intracellular calcium, which occurred at least in part through phospholipase-C-sensitive mechanisms and calcium influx through voltage-operated calcium channels. Short-term exposure of human islets and MIN6 cells to angiotensin II caused a rapid, short-lived initiation of insulin secretion at 2 mmol/l glucose and potentiation of insulin secretion induced by glucose (at 8 and 16.7 mmol/l). CONCLUSIONS/
interpretationThese data demonstrate that the AT(1) is expressed by beta cells and that angiotensin II effects a short-lived and direct stimulation of human and mouse beta cells to promote insulin secretion, most probably through elevations in intracellular calcium. Locally produced angiotensin II may be important in regulating a coordinated insulin secretory response from beta cells.
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