ArticleDigestive diseases and sciences2005
NF-kappaB activation precedes increases in mRNA encoding neurokinin-1 receptor, proinflammatory cytokines, and adhesion molecules in dextran sulfate sodium-induced colitis in rats.
Article in Digestive diseases and sciences, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 59 citations in OpenAlex.
- Time-Resolved Effect of Interferon-Alpha 2a on Activities of Nuclear Factor Kappa B, Pregnane X Receptor and on Drug Disposition Genes.Pharmaceutics · 2021Article
- Neurokinin receptors and their implications in various autoimmune diseases.Current research in immunology · 2021Review
- Article
- Glucose transporter expression in the human colon.World journal of gastroenterology · 2018Article
- Methionine restriction on oxidative stress and immune response in dss-induced colitis mice.Oncotarget · 2017Article
- Impact of basal diet on dextran sodium sulphate (DSS)-induced colitis in rats.European journal of nutrition · 2015Article
- Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a(-/-) mice.World journal of gastrointestinal pharmacology and therapeutics · 2015Article
- Sex differences in gut fermentation and immune parameters in rats fed an oligofructose-supplemented diet.Biology of sex differences · 2015Article
- Integrative approach to analyze biodiversity and anti-inflammatory bioactivity of Wedelia medicinal plants.PloS one · 2015Article
- Substance P participates in immune-mediated hepatic injury induced by concanavalin A in mice and stimulates cytokine synthesis in Kupffer cells.Experimental and therapeutic medicine · 2013Article
- Examination of the Anti-Inflammatory, Antioxidant, and Xenobiotic-Inducing Potential of Broccoli Extract and Various Essential Oils during a Mild DSS-Induced Colitis in Rats.ISRN gastroenterology · 2013Article
- Article
- Impact of adrenomedullin on dextran sulfate sodium-induced inflammatory colitis in mice: insights from in vitro and in vivo experimental studies.International journal of colorectal disease · 2011Article
- Truncated neurokinin-1 receptor is increased in colonic epithelial cells from patients with colitis-associated cancer.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- LITAF mediation of increased TNF-α secretion from inflamed colonic lamina propria macrophages.PloS one · 2011Article
- Overexpression of translocator protein in inflammatory bowel disease: potential diagnostic and treatment value.Inflammatory bowel diseases · 2010Article
- Soybean and fish oil mixture increases IL-10, protects against DNA damage and decreases colonic inflammation in rats with dextran sulfate sodium (DSS) colitis.Lipids in health and disease · 2010Article
- The role of T cell PPAR gamma in mice with experimental inflammatory bowel disease.BMC gastroenterology · 2010Article
- Induction and cellular expression of tartrate resistant acid phosphatase during dextran sodium sulphate induced colitis in rats.Histochemistry and cell biology · 2009Article
- Increased CYP4B1 mRNA is associated with the inhibition of dextran sulfate sodium-induced colitis by caffeic acid in mice.Experimental biology and medicine (Maywood, N.J.) · 2009Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear factor kappa B (NF-kappa B) plays a key role in initiating inflammation associated with colitis. A systematic study was conducted in the rat DSS colitis model to determine the temporal relationship between NF-kappa B activation and expression of substance P (SP), neurokinin-1 receptor (NK-1R), proinflammatory cytokines, and adhesion molecules. Rats were given 5% DSS in their water and sacrificed daily for 6 days. Colon tissue was collected for assessment of histological changes, NF-kappa B activation, myeloperoxidase (MPO) activity, and expression of NK-1R, SP, TNFalpha, IL-1beta, VCAM-1, ICAM-1, E-selectin, CINC-1, MIP-1alpha, and iNOS. NF-kappa B activation increased, biphasically, on Day 1 and again on Days 4-6. The mRNA levels for ICAM-1, CINC-1, IL-1beta, TNFalpha, VCAM-1, and NK-1R rose significantly (P < 0.05) by 2-4 days. Increased iNOS mRNA levels, MPO activity, and mucosal damage occurred on Day 6. These data demonstrate that NF-kappa B activation substantially precedes the onset of physical disease signs and active inflammation.
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