ArticleDigestive diseases and sciences2005
Inadequate use of acid-suppressive therapy in hospitalized patients and its implications for general practice.
Article in Digestive diseases and sciences, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Pooled it
- Current practice of stress ulcer prophylaxis in a surgical patient cohort in a German university hospital.Langenbeck's archives of surgery · 2021Article
- Current Practice of Stress Ulcer Prophylaxis in Surgical Departments in Mecklenburg Western Pomerania, Germany.Healthcare (Basel, Switzerland) · 2021Article
- Prescription Pattern of Proton Pump Inhibitors at Hospital Admission and Discharge.GE Portuguese journal of gastroenterology · 2019Article
- Acid-Suppressive Therapy and Risk of Infections: Pros and Cons.Clinical drug investigation · 2017Review
- Imprudent Gastro-protective Approach in Majority of Specialists' Clinics of a Tertiary Hospital.Journal of clinical and diagnostic research : JCDR · 2016Article
- Improving appropriateness of acid-suppressive medication use via computerized clinical decision support.Journal of hospital medicine · 2015Article
- Inappropriate use of proton pump inhibitors in a local setting.Singapore medical journal · 2014Article
- Stress ulcer prophylaxis guidelines: Are they being implemented in Lebanese health care centers?World journal of gastrointestinal pharmacology and therapeutics · 2011Article
- Acid-suppressive medication use and the risk for nosocomial gastrointestinal tract bleeding.Archives of internal medicine · 2011Article
- Appropriateness of treatment recommendations for PPI in hospital discharge letters.European journal of clinical pharmacology · 2010Article
- Overprescribing PPIs: Time for a hospital antacid policy on Clostridium difficile.BMJ (Clinical research ed.) · 2008Article
- Impact of targeted educational interventions on appropriateness of stress ulcer prophylaxis in critically ill adults.Pharmacy practiceArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acid-suppressive therapy (AST) is largely prescribed in both hospital and general practice setting but few data are available on appropriateness of AST use in hospitalized patients and its fallout on prescribing in general practice. We assessed AST in patients consecutively admitted to an internal medicine department to determine the type and timing of prescription and indication for use according to widely accepted guidelines. Prescriptions were rated as indicated, acceptable, or not indicated. Overall, 58.7% of 834 admitted patients received AST, mainly proton pump inhibitors. The prescriptions were indicated in 50.1% of patients, not indicated in 41.5%, and acceptable in 6.5%. The main reason for inappropriate use was prophylaxis in low-risk patients (64.8%). On admission, 35.7% of 112 patients already on AST were judged to receive inappropriate prescription; of 348 patients discharged on AST, overuse was identified in 38.5%. No significant difference was observed for inappropriate use at admission, during hospitalization, and at discharge. In 64 inpatients (7.7%) AST, although indicated, mainly for ulcer prophylaxis in high-risk patients, was not prescribed. In conclusion, AST is substantially over-used in both hospital and general practice settings, mainly for ulcer prophylaxis in low-risk patients. On the other hand, AST is underused in a small, but not negligible proportion of high-risk patients.
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