ArticleEuropean biophysics journal : EBJ2006
A target function for quaternary structural refinement from small angle scattering and NMR orientational restraints.
Article in European biophysics journal : EBJ, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Computational and Experimental Approaches and Applications of Biological NMR.Advances in experimental medicine and biology · 2026Review
- Combining NMR and small angle X-ray scattering for the study of biomolecular structure and dynamics.Archives of biochemistry and biophysics · 2017Review
- Hybrid Methods in Iron-Sulfur Cluster Biogenesis.Frontiers in molecular biosciences · 2017Review
- Modeling macromolecular motions by x-ray-scattering-constrained molecular dynamics.Biophysical journal · 2015Article
- Uniqueness of models from small-angle scattering data: the impact of a hydration shell and complementary NMR restraints.Acta crystallographica. Section D, Biological crystallography · 2015Article
- The dynamic duo: combining NMR and small angle scattering in structural biology.Protein science : a publication of the Protein Society · 2014Review
- HierarchicalJournal of applied crystallography · 2014Article
- Combining NMR and small angle X-ray and neutron scattering in the structural analysis of a ternary protein-RNA complex.Journal of biomolecular NMR · 2013Article
- A simple procedure to evaluate the efficiency of bio-macromolecular rigid-body refinement by small-angle scattering.European biophysics journal : EBJ · 2012Article
- A refinement protocol to determine structure, topology, and depth of insertion of membrane proteins using hybrid solution and solid-state NMR restraints.Journal of biomolecular NMR · 2009Article
- Stability and kinetics of G-quadruplex structures.Nucleic acids research · 2008Review
- Solution structure of tRNAVal from refinement of homology model against residual dipolar coupling and SAXS data.Journal of biomolecular NMR · 2008Article
- A structure refinement protocol combining NMR residual dipolar couplings and small angle scattering restraints.Journal of biomolecular NMR · 2008Article
- Refined solution structure of the 82-kDa enzyme malate synthase G from joint NMR and synchrotron SAXS restraints.Journal of biomolecular NMR · 2008Article
- A simple genetic algorithm for the optimization of multidomain protein homology models driven by NMR residual dipolar coupling and small angle X-ray scattering data.European biophysics journal : EBJ · 2007Article
- X-ray scattering combined with coordinate-based analyses for applications in natural and artificial photosynthesis.Photosynthesis researchReview
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3 authors.
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Abstract
We present a novel target function based on atomic coordinates that permits quaternary structural refinement of multi-domain protein-protein or protein-RNA complexes. It requires that the high-resolution structures of the individual domains are known and that small angle scattering (SAS) data as well as NMR orientational restraints from residual dipolar couplings (RDCs) of the complex are available. We show that, when used in combination, the translational and rotational restraints contained in SAS intensities and RDCs, respectively, define a target potential function that permits to determine the overall topology of complexes made up of domains with low internal symmetry. We apply the target function on a modestly anisotropic model system, the Barnase/Barstar complex, and discuss factors that influence the structural refinement such as data errors and the geometrical properties of the individual domains.
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