ArticleMammalian genome : official journal of the International Mammalian Genome Society2006
The mutation causing the black-and-tan pigmentation phenotype of Mangalitza pigs maps to the porcine ASIP locus but does not affect its coding sequence.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 77 citations in OpenAlex.
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- Coat colour phenotype of Qingyu pig is associated with polymorphisms of melanocortin receptor 1 gene.Asian-Australasian journal of animal sciences · 2017Article
- The origin of chow chows in the light of the East Asian breeds.BMC genomics · 2017Article
- Domestic animals as models for biomedical research.Upsala journal of medical sciences · 2016Review
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- Genome sequencing and analysis of Mangalica, a fatty local pig of Hungary.BMC genomics · 2014Article
- Introgression and isolation contributed to the development of Hungarian Mangalica pigs from a particular European ancient bloodline.Genetics, selection, evolution : GSE · 2013Article
- Agouti revisited: transcript quantification of the ASIP gene in bovine tissues related to protein expression and localization.PloS one · 2012Article
- A 6-bp deletion in the TYRP1 gene causes the brown colouration phenotype in Chinese indigenous pigs.Heredity · 2011Article
- A robust linkage map of the porcine autosomes based on gene-associated SNPs.BMC genomics · 2009Article
- Contrasting mode of evolution at a coat color locus in wild and domestic pigs.PLoS genetics · 2009Article
- A gene duplication affecting expression of the ovine ASIP gene is responsible for white and black sheep.Genome research · 2008Article
- Investigation of the role of the agouti signaling protein gene (ASIP) in coat color evolution in primates.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
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8 authors at 5 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
The gene for agouti signaling protein (ASIP) is centrally involved in the expression of coat color traits in animals. The Mangalitza pig breed is characterized by a black-and-tan phenotype with black dorsal pigmentation and yellow or white ventral pigmentation. We investigated a Mangalitza x Piétrain cross and observed a coat color segregation pattern in the F2 generation that can be explained by virtue of two alleles at the MC1R locus and two alleles at the ASIP locus. Complete linkage of the black-and-tan phenotype to microsatellite alleles at the ASIP locus on SSC 17q21 was observed. Corroborated by the knowledge of similar mouse coat color mutants, it seems therefore conceivable that the black-and-tan pigmentation of Mangalitza pigs is caused by an ASIP allele a(t), which is recessive to the wild-type allele A. Toward positional cloning of the a(t) mutation, a 200-kb genomic BAC/PAC contig of this chromosomal region has been constructed and subsequently sequenced. Full-length ASIP cDNAs obtained by RACE differed in their 5' untranslated regions, whereas they shared a common open reading frame. Comparative sequencing of all ASIP exons and ASIP cDNAs between Mangalitza and Piétrain pigs did not reveal any differences associated with the coat color phenotype. Relative qRT-PCR analyses showed different dorsoventral skin expression intensities of the five ASIP transcripts in black-and-tan Mangalitza. The a(t) mutation is therefore probably a regulatory ASIP mutation that alters its dorsoventral expression pattern.
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