ReviewHeart failure reviews2005
Thin filament remodeling in failing myocardium.
Review in Heart failure reviews, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Sphingosine-1-Phosphate Receptor Modulator, FTY720, Improves Diastolic Dysfunction and Partially Reverses Atrial Remodeling in a Tm-E180G Mouse Model Linked to Hypertrophic Cardiomyopathy.Circulation. Heart failure · 2019Article
- The effect of sildenafil on right ventricular remodeling in a rat model of monocrotaline-induced right ventricular failure.Korean journal of pediatrics · 2016Article
- Right ventricular failure and pathobiology in patients with congenital heart disease - implications for long-term follow-up.Frontiers in pediatrics · 2013Review
- TNNI3K is a novel mediator of myofilament function and phosphorylates cardiac troponin I.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2013Article
- Reversal of isoflurane-induced depression of myocardial contraction by nitroxyl via myofilament sensitization to Ca2+.The Journal of pharmacology and experimental therapeutics · 2011Article
- Protein Kinases as Drug Development Targets for Heart Disease Therapy.Pharmaceuticals (Basel, Switzerland) · 2010Review
- ANKRD1, the gene encoding cardiac ankyrin repeat protein, is a novel dilated cardiomyopathy gene.Journal of the American College of Cardiology · 2009Article
- Left ventricular twist mechanics in a canine model of reversible congestive heart failure: a pilot study.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2009Article
- Tuning cardiac performance in ischemic heart disease and failure by modulating myofilament function.Journal of molecular medicine (Berlin, Germany) · 2007Review
- Single amino acid substitutions define isoform-specific effects of troponin I on myofilament Ca2+ and pH sensitivity.Journal of molecular and cellular cardiology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
While the remodeling process in myocardial failure involves changes in ventricular structure and performance, it is now appreciated that it is also associated with changes in thin filament composition and function. As is discussed, changes at the level thick filament may affect thin filament activation in heart failure. Alterations in actin, troponin and tropomyosin isoform composition do not appear to be significant factors in human heart failure. In contrast, proteolytic degradation of troponin subunits are likely to be playing a functional role in some forms of cardiomyopathy (e.g. ischemic). Finally, phosphorylation of troponin I and troponin T by kinases (most notably protein kinase C) substantially affect thin filament function in failing human myocardium. These findings indicate that functional deficits in thin filament function in failing myocardium are largely reversible and create the potential for future targeted therapies in the treatment of this deadly disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.