ArticleNature cell biology2006
The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation.
Article in Nature cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed, 135 citations in OpenAlex.
- H3K27me3-mediated epigenetic regulation in pluripotency maintenance and lineage differentiation.Cell insight · 2024Review
- Quiescence enables unrestricted cell fate in naive embryonic stem cells.Nature communications · 2024Article
- Review
- Epigenetic Reprogramming inCells · 2023Review
- Activation of Xist by an evolutionarily conserved function of KDM5C demethylase.Nature communications · 2022Article
- Preventing erosion of X-chromosome inactivation in human embryonic stem cells.Nature communications · 2022Article
- Gene regulation in time and space during X-chromosome inactivation.Nature reviews. Molecular cell biology · 2022Review
- The control of polycomb repressive complexes by long noncoding RNAs.Wiley interdisciplinary reviews. RNA · 2021Review
- H4K20me1 and H3K27me3 are concurrently loaded onto the inactive X chromosome but dispensable for inducing gene silencing.EMBO reports · 2021Article
- Subcellular localization of EZH2 phosphorylated at T367 stratifies metaplastic breast carcinoma subtypes.Breast cancer (Tokyo, Japan) · 2021Article
- Review
- Progress toward understanding chromosome silencing by Xist RNA.Genes & development · 2020Review
- The many faces of Polycomb regulation by RNA.Current opinion in genetics & development · 2020Review
- Multimodal Long Noncoding RNA Interaction Networks: Control Panels for Cell Fate Specification.Genetics · 2019Review
- The role of Xist-mediated Polycomb recruitment in the initiation of X-chromosome inactivation.EMBO reports · 2019Article
- lncRNA-Induced Spread of Polycomb Controlled by Genome Architecture, RNA Abundance, and CpG Island DNA.Molecular cell · 2019Article
- Article
- Alteration of Epigenetic Regulation by Long Noncoding RNAs in Cancer.International journal of molecular sciences · 2018Review
- Polycomb complexes in X chromosome inactivation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Long non-coding RNAs as an epigenetic regulator in human cancers.Cancer science · 2017Review
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The Polycomb group (PcG) encodes an evolutionarily conserved set of chromatin-modifying proteins that are thought to maintain cellular transcriptional memory by stably silencing gene expression. In mouse embryos that are mutated for the PcG protein Eed, X-chromosome inactivation (XCI) is not stably maintained in extra-embryonic tissues. Eed is a component of a histone-methyltransferase complex that is thought to contribute to stable silencing in undifferentiated cells due to its enrichment on the inactive X-chromosome in cells of the early mouse embryo and in stem cells of the extra-embryonic trophectoderm lineage. Here, we demonstrate that the inactive X-chromosome in Eed(-/-) trophoblast stem cells and in cells of the trophectoderm-derived extra-embryonic ectoderm in Eed(-/-) embryos remain transcriptionally silent, despite lacking the PcG-mediated histone modifications that normally characterize the facultative heterochromatin of the inactive X-chromosome. Whereas undifferentiated Eed(-/-) trophoblast stem cells maintained XCI, reactivation of the inactive X-chromosome occurred when these cells were differentiated. These results indicate that PcG complexes are not necessary to maintain transcriptional silencing of the inactive X-chromosome in undifferentiated stem cells. Instead, PcG proteins seem to propagate cellular memory by preventing transcriptional activation of facultative heterochromatin during differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.