ArticleGenetics2006
A novel forward genetic screen for identifying mutations affecting larval neuronal dendrite development in Drosophila melanogaster.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Nascent dendrite branches initiated by a localized burst of Spire-dependent actin polymerization.Development (Cambridge, England) · 2025Article
- Patronin governs minus-end-out orientation of dendritic microtubules to promote dendrite pruning ineLife · 2019Article
- Article
- Dendrite architecture organized by transcriptional control of the F-actin nucleator Spire.Development (Cambridge, England) · 2014Article
- Isolation of AMP-activated protein kinase (AMPK) alleles required for neuronal maintenance in Drosophila melanogaster.Biology open · 2013Article
- The kinesin-3, unc-104 regulates dendrite morphogenesis and synaptic development in Drosophila.Genetics · 2013Article
- MMAPPR: mutation mapping analysis pipeline for pooled RNA-seq.Genome research · 2013Article
- Article
- In vivo imaging of the actin polymerization state with two-photon fluorescence anisotropy.Biophysical journal · 2012Article
- Morphological analysis of Drosophila larval peripheral sensory neuron dendrites and axons using genetic mosaics.Journal of visualized experiments : JoVE · 2011Article
- Neuronal remodeling and apoptosis require VCP-dependent degradation of the apoptosis inhibitor DIAP1.Development (Cambridge, England) · 2011Article
- Identification of a nuclear export signal in the catalytic subunit of AMP-activated protein kinase.Molecular biology of the cell · 2010Article
- Molecules and mechanisms of dendrite development in Drosophila.Development (Cambridge, England) · 2009Review
- The actin-binding protein capulet genetically interacts with the microtubule motor kinesin to maintain neuronal dendrite homeostasis.PloS one · 2008Article
- Identification of genes influencing dendrite morphogenesis in developing peripheral sensory and central motor neurons.Neural development · 2008Article
- LKB1 and AMPK maintain epithelial cell polarity under energetic stress.The Journal of cell biology · 2007Article
- Transcriptional control of dendritic patterning in Drosophila neurons.Genome biology · 2006Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Vertebrate and invertebrate dendrites are information-processing compartments that can be found on both central and peripheral neurons. Elucidating the molecular underpinnings of information processing in the nervous system ultimately requires an understanding of the genetic pathways that regulate dendrite formation and maintenance. Despite the importance of dendrite development, few forward genetic approaches have been used to analyze the latest stages of dendrite development, including the formation of F-actin-rich dendritic filopodia or dendritic spines. We developed a forward genetic screen utilizing transgenic Drosophila second instar larvae expressing an actin, green fluorescent protein (GFP) fusion protein (actin::GFP) in subsets of sensory neurons. Utilizing this fluorescent transgenic reporter, we conducted a forward genetic screen of >4000 mutagenized chromosomes bearing lethal mutations that affected multiple aspects of larval dendrite development. We isolated 13 mutations on the X and second chromosomes composing 11 complementation groups affecting dendrite outgrowth/branching, dendritic filopodia formation, or actin::GFP localization within dendrites in vivo. In a fortuitous observation, we observed that the structure of dendritic arborization (da) neuron dendritic filopodia changes in response to a changing environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.