ArticleGenetics2006
Regulation of hyphal morphogenesis and the DNA damage response by the Aspergillus nidulans ATM homolog AtmA.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- A CRISPR-Cas9-based system for the dose-dependent study of DNA double-strand break sensing and repair.The FEBS journal · 2025Article
- ATM in breast and brain tumors: a comprehensive review.Cancer biology & medicine · 2018Article
- The Aspergillus nidulans ATM kinase regulates mitochondrial function, glucose uptake and the carbon starvation response.G3 (Bethesda, Md.) · 2014Article
- The contribution of the S-phase checkpoint genes MEC1 and SGS1 to genome stability maintenance in Candida albicans.Fungal genetics and biology : FG & B · 2011Article
- The RHO1-specific GTPase-activating protein LRG1 regulates polar tip growth in parallel to Ndr kinase signaling in Neurospora.Molecular biology of the cell · 2008Article
- Regulation of apical dominance in Aspergillus nidulans hyphae by reactive oxygen species.Genetics · 2008Article
- Functional characterization of the putative Aspergillus nidulans DNA damage binding protein homologue DdbA.Molecular genetics and genomics : MGG · 2008Article
- Genetic interactions of the Aspergillus nidulans atmAATM homolog with different components of the DNA damage response pathway.Genetics · 2008Article
- Ras GTPase-activating protein regulation of actin cytoskeleton and hyphal polarity in Aspergillus nidulans.Eukaryotic cell · 2008Article
- Role of DNA mismatch repair and double-strand break repair in genome stability and antifungal drug resistance in Candida albicans.Eukaryotic cell · 2007Article
- A point mutation in the Aspergillus nidulans sonBNup98 nuclear pore complex gene causes conditional DNA damage sensitivity.Genetics · 2006Article
- Transcriptome analysis of Aspergillus nidulans exposed to camptothecin-induced DNA damage.Eukaryotic cell · 2006Article
- The fission yeast DNA structure checkpoint protein Rad26ATRIP/LCD1/UVSD accumulates in the cytoplasm following microtubule destabilization.BMC cell biology · 2006Article
- Functional characterization of the putative Aspergillus nidulans poly(ADP-ribose) polymerase homolog PrpA.Genetics · 2006Article
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Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ataxia telangiectasia (A-T) is an inherited disorder characterized by progressive loss of motor function and susceptibility to cancer. The most prominent clinical feature observed in A-T patients is the degeneration of Purkinje motor neurons. Numerous studies have emphasized the role of the affected gene product, ATM, in the regulation of the DNA damage response. However, in Purkinje cells, the bulk of ATM localizes to the cytoplasm and may play a role in vesicle trafficking. The nature of this function, and its involvement in the pathology underlying A-T, remain unknown. Here we characterize the homolog of ATM (AtmA) in the filamentous fungus Aspergillus nidulans. In addition to its expected role in the DNA damage response, we find that AtmA is also required for polarized hyphal growth. We demonstrate that an atmA mutant fails to generate a stable axis of hyphal polarity. Notably, cytoplasmic microtubules display aberrant cortical interactions at the hyphal tip. Our results suggest that AtmA regulates the function and/or localization of landmark proteins required for the formation of a polarity axis. We propose that a similar function may contribute to the establishment of neuronal polarity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.