Evidence map›Paper›PMID 16415336›Full record

SynthesisBMJ (Clinical research ed.)2006

Compliance with QUOROM and quality of reporting of overlapping meta-analyses on the role of acetylcysteine in the prevention of contrast associated nephropathy: case study.

Giuseppe G L Biondi-Zoccai, Marzia Lotrionte, Antonio Abbate, Luca Testa, Enrico Remigi, Francesco Burzotta, Marco Valgimigli, Enrico Romagnoli, Filippo Crea, Pierfrancesco Agostoni

Abstract readMeta-AnalysisReview
In one paragraph

Synthesis in BMJ (Clinical research ed.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 12 syntheses or guidelines pooled it.

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  12. The cost-effectiveness of drug-eluting stents: a systematic review.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2007
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Giuseppe G L Biondi-ZoccaiHemodynamics and Cardiovascular Radiology Service, Policlinico San Donato, Via Morandi 30, 20097 San Donato Milanese, Italy. gbiondizoccai@gmail.com
Marzia Lotrionte
Antonio Abbate
Luca Testa
Enrico Remigi
Francesco Burzotta
Marco Valgimigli
Enrico Romagnoli
Filippo Crea
Pierfrancesco Agostoni

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo appraise multiple systematic reviews on the same clinical topic, focusing on predictors and correlates of quality of reporting of meta-analysis (QUOROM) scores.

designCase study.

settingReviews providing at least individual quantitative estimates on role of acetylcysteine in the prevention of contrast associated nephropathy. DATA SOURCES: PubMed, the database of abstracts of reviews of effects, and the Cochrane database of systematic reviews (updated March 2005).

main outcome measuresFunding, compliance with the QUOROM checklist, scores on the Oxman and Guyatt quality index, and authors' recommendations.

results10 systematic reviews, published August 2003 to March 2005, were included. Nine pooled events despite heterogeneity and five recommended routine use of acetylcysteine, whereas the remaining studies called for further research. Compliance with the 18 items on the QUOROM checklist was relatively high (median 16, range 11 to 17), although shorter manuscripts had significantly lower scores (R = 0.73; P = 0.016). Reviewers who reported previous not for profit funding were more likely to score higher on the Oxman and Guyatt quality index. No association was found between QUOROM and Oxman and Guyatt scores (R = -0.06; P = 0.86), mainly because of greater emphasis of the Oxman and Guyatt scores on the appraisal of bias in selection and validity assessment (inadequate in five reviews).

conclusionsMultiple systematic reviews on the same clinical topic varied in quality of reporting and recommendations. Longer manuscripts and previous not for profit funding were associated with higher quality.

Indexed as

Meta-Analysis as TopicAcetylcysteineContrast MediaGuideline AdherenceHumansJournalism, MedicalKidney DiseasesQuality ControlRandomized Controlled Trials as TopicResearch Support as TopicReview Literature as TopicAcetylcysteineContrast Media

Identifiers

PMID16415336
PMCPMC1352049

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.