ArticlePlant physiology2006
G-protein-coupled receptor 1, G-protein Galpha-subunit 1, and prephenate dehydratase 1 are required for blue light-induced production of phenylalanine in etiolated Arabidopsis.
Article in Plant physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 123 citations in OpenAlex.
- The atomistic Mechanism Underlying Regulation of the GPA1 G Protein Signaling Pathway Mediated by Abscisic Acid (ABA) Phytohormone Binding to the GCR1 Plant G Protein Coupled Receptor.Journal of chemical information and modeling · 2026Article
- Is GCR1 the GPR157 of plants?Plant physiology · 2025Article
- Evolution of aromatic amino acid metabolism in plants: a key driving force behind plant chemical diversity in aromatic natural products.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Overexpression ofPlants (Basel, Switzerland) · 2024Article
- Soybean AROGENATE DEHYDRATASES (GmADTs): involvement in the cytosolic isoflavonoid metabolon or trans-organelle continuity?Frontiers in plant science · 2024Article
- Phenylpropanoid-enriched broccoli seedling extract can reduce inflammatory markers and pain behavior.Journal of translational medicine · 2023Article
- Nitrate-responsive transcriptome analysis of rice RGA1 mutant reveals the role of G-protein alpha subunit in negative regulation of nitrogen-sensitivity and use efficiency.Plant cell reports · 2023Article
- Life, death and resurrection of plant GPCRs.Plant molecular biology · 2023Review
- Arogenate dehydratases: unique roles in light-directed development during the seed-to-seedling transition inFrontiers in plant science · 2023Article
- Article
- Heterotrimeric G-protein α subunit (RGA1) regulates tiller development, yield, cell wall, nitrogen response and biotic stress in rice.Scientific reports · 2021Article
- A Sugarcane G-Protein-Coupled Receptor,Frontiers in plant science · 2021Article
- Heterotrimeric G-Protein Interactions Are Conserved Despite Regulatory Element Loss in Some Plants.Plant physiology · 2020Article
- Plant receptor-like kinase signaling through heterotrimeric G-proteins.Journal of experimental botany · 2020Review
- An Age-Dependent Sequence of Physiological Processes Defines Developmental Root Senescence.Plant physiology · 2019Article
- GCR1 and GPA1 coupling regulates nitrate, cell wall, immunity and light responses in Arabidopsis.Scientific reports · 2019Article
- Completion of the cytosolic post-chorismate phenylalanine biosynthetic pathway in plants.Nature communications · 2019Article
- Characterization of Heterotrimeric G Protein γ4 Subunit in Rice.International journal of molecular sciences · 2018Article
- Identification of Heterotrimeric G Protein γ3 Subunit in Rice Plasma Membrane.International journal of molecular sciences · 2018Article
- The G ProteinPlant physiology · 2018Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Different classes of plant hormones and different wavelengths of light act through specific signal transduction mechanisms to coordinate higher plant development. A specific prephenate dehydratase protein (PD1) was discovered to have a strong interaction with the sole canonical G-protein Galpha-subunit (GPA1) in Arabidopsis (Arabidopsis thaliana). PD1 is a protein located in the cytosol, present in etiolated seedlings, with a specific role in blue light-mediated synthesis of phenylpyruvate and subsequently of phenylalanine (Phe). Insertion mutagenesis confirms that GPA1 and the sole canonical G-protein-coupled receptor (GCR1) in Arabidopsis also have a role in this blue light-mediated event. In vitro analyses indicate that the increase in PD1 activity is the direct and specific consequence of its interaction with activated GPA1. Because of their shared role in the light-mediated synthesis of phenylpyruvate and Phe, because they are iteratively interactive, and because activated GPA1 is directly responsible for the activation of PD1; GCR1, GPA1, and PD1 form all of or part of a signal transduction mechanism responsible for the light-mediated synthesis of phenylpyruvate, Phe, and those metabolites that derive from that Phe. Data are also presented to confirm that abscisic acid can act through the same pathway. An additional outcome of the work is the confirmation that phenylpyruvate acts as the intermediate in the synthesis of Phe in etiolated plants, as it commonly does in bacteria and fungi.
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