ArticlePlant physiology2006
High-affinity nitrate transport in roots of Arabidopsis depends on expression of the NAR2-like gene AtNRT3.1.
Article in Plant physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
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93 citing papers in PubMed, 254 citations in OpenAlex.
- TheInternational journal of molecular sciences · 2026Article
- SaNAR2.2, A Novel Member of the NAR2 Family from the EuhalophyteMembranes · 2026Article
- HHO5 orchestrates dose-dependent feedback regulation of organic versus inorganic nitrogen signaling in Arabidopsis.The Plant cell · 2026Article
- Transcriptional regulation modulates nitrate uptake and utilization ofFrontiers in plant science · 2026Article
- Article
- Decoding nitrogen uptake efficiency in maize and sorghum: insights from comparative gene regulatory networks.The Plant journal : for cell and molecular biology · 2025Article
- Article
- Spinach SoNRT3 Interacts with SoNRT2a to Improve Low-Nitrogen Tolerance via Nitrate Uptake and Root Growth.Plants (Basel, Switzerland) · 2025Article
- BdNRT2A and BdNRT3.2 Are the Major Components of the High-Affinity Nitrate Transport System inPlant direct · 2025Article
- Beyond nitrate transport: AtNRT2.4 responds to local and systemic nitrogen signaling in Arabidopsis.BMC plant biology · 2025Article
- Natural variation in ZmNRT2.5 modulates husk leaf width and promotes seed protein content in maize.Plant biotechnology journal · 2025Article
- Characterization of nitrate use efficiency in tea plant (Horticulture research · 2025Article
- Article
- Genome-wide identification, evolution and expression analysis unveil the role ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
- Genome-Wide Identification and Expression Analysis of Nitrate Transporter (NRT) Gene Family inGenes · 2024Article
- Physiological, molecular, and environmental insights into plant nitrogen uptake, and metabolism under abiotic stresses.The plant genome · 2024Review
- Article
- Functional analyses of the NRT2 family of nitrate transporters inFrontiers in plant science · 2024Review
- The Functional Diversity of the High-Affinity Nitrate Transporter Gene Family in Hexaploid Wheat: Insights from Distinct Expression Profiles.International journal of molecular sciences · 2023Article
- Nitrogen Journey in Plants: From Uptake to Metabolism, Stress Response, and Microbe Interaction.Biomolecules · 2023Review
33 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The NAR2 protein of Chlamydomonas reinhardtii has no known transport activity yet it is required for high-affinity nitrate uptake. Arabidopsis (Arabidopsis thaliana) possesses two genes, AtNRT3.1 and AtNRT3.2, that are similar to the C. reinhardtii NAR2 gene. AtNRT3.1 accounts for greater than 99% of NRT3 mRNA and is induced 6-fold by nitrate. AtNRT3.2 was expressed constitutively at a very low level and did not compensate for the loss of AtNRT3.1 in two Atnrt3.1 mutants. Nitrate uptake by roots and nitrate induction of gene expression were analyzed in two T-DNA mutants, Atnrt3.1-1 and Atnrt3.1-2, disrupted in the AtNRT3.1 promoter and coding regions, respectively, in 5-week-old plants. Nitrate induction of the nitrate transporter genes AtNRT1.1 and AtNRT2.1 was reduced in Atnrt3.1 mutant plants, and this reduced expression was correlated with reduced nitrate concentrations in the tissues. Constitutive high-affinity influx was reduced by 34% and 89%, respectively, in Atnrt3.1-1 and Atnrt3.1-2 mutant plants, while high-affinity nitrate-inducible influx was reduced by 92% and 96%, respectively, following induction with 1 mm KNO(3) after 7 d of nitrogen deprivation. By contrast, low-affinity influx appeared to be unaffected. Thus, the constitutive high-affinity influx and nitrate-inducible high-affinity influx (but not the low-affinity influx) of higher plant roots require a functional AtNRT3 (NAR2) gene.
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