ArticleBiophysical journal2006
Deterministic model of dermal wound invasion incorporating receptor-mediated signal transduction and spatial gradient sensing.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed.
- Spatio-temporal multiscale cell modeling of skin wound healing.Biophysical journal · 2026Article
- Emergent eukaryotic directional sensing via receptor degradation and diffusion.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Semi-autonomous wound invasion via matrix-deposited, haptotactic cues.Journal of theoretical biology · 2023Article
- Stability of a two-dimensional biomorphoelastic model for post-burn contraction.Journal of mathematical biology · 2023Article
- Sensitivity of a two-dimensional biomorphoelastic model for post-burn contraction.Biomechanics and modeling in mechanobiology · 2023Article
- A self-generated Toddler gradient guides mesodermal cell migration.Science advances · 2022Article
- Sensitivity and feasibility of a one-dimensional morphoelastic model for post-burn contraction.Biomechanics and modeling in mechanobiology · 2021Article
- Stability of a one-dimensional morphoelastic model for post-burn contraction.Journal of mathematical biology · 2021Article
- Mathematical Modeling Can Advance Wound Healing Research.Advances in wound care · 2021Review
- A multiphase model of growth factor-regulated atherosclerotic cap formation.Journal of mathematical biology · 2020Article
- Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensing.PLoS computational biology · 2020Article
- Advanced 2D/3D cell migration assay for faster evaluation of chemotaxis of slow-moving cells.PloS one · 2019Article
- Cell Sequence and Mitosis Affect Fibroblast Directional Decision-Making During Chemotaxis in Microfluidic Mazes.Cellular and molecular bioengineering · 2018Article
- Collective gradient sensing and chemotaxis: modeling and recent developments.Journal of physics. Condensed matter : an Institute of Physics journal · 2018Review
- Programmed biomolecule delivery to enable and direct cell migration for connective tissue repair.Nature communications · 2017Article
- A Reaction-Diffusion Model Explains Amplification of the PLC/PKC Pathway in Fibroblast Chemotaxis.Biophysical journal · 2017Article
- Physical models of collective cell motility: from cell to tissue.Journal of physics D: Applied physics · 2017Article
- Local modulation of chemoattractant concentrations by single cells: dissection using a bulk-surface computational model.Interface focus · 2016Article
- Self-Generated Chemoattractant Gradients: Attractant Depletion Extends the Range and Robustness of Chemotaxis.PLoS biology · 2016Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During dermal wound healing, platelet-derived growth factor (PDGF) serves as both a chemoattractant and mitogen for fibroblasts, potently stimulating their invasion of the fibrin clot over a period of several days. A mathematical model of this process is presented, which accurately accounts for the sensitivity of PDGF gradient sensing through PDGF receptor/phosphoinositide 3-kinase-mediated signal transduction. Analysis of the model suggests that PDGF receptor-mediated endocytosis and degradation of PDGF allows a constant PDGF concentration profile to be maintained at the leading front of the fibroblast density profile as it propagates, at a constant rate, into the clot. Thus, the constant PDGF gradient can span the optimal concentration range for asymmetric phosphoinositide 3-kinase signaling and fibroblast chemotaxis, with near-maximal invasion rates elicited over a relatively broad range of PDGF secretion rates. A somewhat surprising finding was that extremely sharp PDGF gradients do not necessarily stimulate faster progression through the clot, because maintaining such a gradient through PDGF consumption is a potentially rate-limiting process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.