ArticleJournal of virology2006
Rapid expression of human immunodeficiency virus following activation of latently infected cells.
Article in Journal of virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- World free HIV: the novel therapeutic approaches for eliminating latent HIV infection.Virology journal · 2026Review
- Animal Models for HIV Cure Research.Frontiers in immunology · 2016Review
- Studies of retroviral infection in humanized mice.Virology · 2015Review
- An HIV-1 replication pathway utilizing reverse transcription products that fail to integrate.Journal of virology · 2013Article
- Dendritic cell-induced activation of latent HIV-1 provirus in actively proliferating primary T lymphocytes.PLoS pathogens · 2013Article
- Achieving a cure for HIV infection: do we have reasons to be optimistic?The Journal of antimicrobial chemotherapy · 2012Review
- HIV latency in the humanized BLT mouse.Journal of virology · 2012Article
- Directly infected resting CD4+T cells can produce HIV Gag without spreading infection in a model of HIV latency.PLoS pathogens · 2012Article
- HIV latency is influenced by regions of the viral genome outside of the long terminal repeats and regulatory genes.Virology · 2011Article
- Activation of latent HIV using drug-loaded nanoparticles.PloS one · 2011Article
- HIV reservoirs and latency models.Virology · 2011Review
- Establishment and maintenance of HIV latency: model systems and opportunities for intervention.Future virology · 2010Article
- Can the viral reservoir of latently infected CD4(+) T cells be eradicated with antiretroviral HIV drugs?Journal of mathematical biology · 2009Article
- Epigenetic silencing of human immunodeficiency virus (HIV) transcription by formation of restrictive chromatin structures at the viral long terminal repeat drives the progressive entry of HIV into latency.Journal of virology · 2008Article
- CBF-1 promotes transcriptional silencing during the establishment of HIV-1 latency.The EMBO journal · 2007Article
- Vpr is required for efficient Nef expression from unintegrated human immunodeficiency virus type 1 DNA.Journal of virology · 2007Article
- Centrosomal latency of incoming foamy viruses in resting cells.PLoS pathogens · 2007Article
- Immediate activation fails to rescue efficient human immunodeficiency virus replication in quiescent CD4+ T cells.Journal of virology · 2007Article
- Novel in vivo model for the study of human immunodeficiency virus type 1 transcription inhibitors: evaluation of new 6-desfluoroquinolone derivatives.Antimicrobial agents and chemotherapy · 2007Article
- HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-gamma c-/- (RAG-hu) mouse model.Retrovirology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The host cell activation state impacts the nature of human immunodeficiency virus infection. Activated cells facilitate productive infections; quiescent cells enable the virus to enter a latent state, the major obstacle to viral clearance. We wanted to understand how these differences affected viral gene expression. In quiescent cells activated prior to infection, viral RNA was seen 12 h postinfection; when cells were stimulated postinfection, viral RNA was not seen until 36 h postinfection. Up-regulation of viral RNA in latently infected cells occurred within 2 h poststimulation. This hierarchy also held true for viral protein production. These results may explain the rapid reemergence of viremia following termination of therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.