ArticleJournal of vascular surgery2006
Bone morphogenetic protein 4: potential regulator of shear stress-induced graft neointimal atrophy.
Article in Journal of vascular surgery, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Biostimulatory Effects of Low-Intensity Pulsed Ultrasound on Rate of Orthodontic Tooth Movement and Associated Pain, Applied at 3-Week Intervals: A Split-Mouth Study.Pain research & management · 2021Article
- High shear stress induces atherosclerotic vulnerable plaque formation through angiogenesis.Regenerative biomaterials · 2016Review
- Regulators and effectors of bone morphogenetic protein signalling in the cardiovascular system.The Journal of physiology · 2015Review
- Biomechanical regulation of vascular smooth muscle cell functions: from in vitro to in vivo understanding.Journal of the Royal Society, Interface · 2014Review
- Hemodynamic Shear Stress and Endothelial Dysfunction in Hemodialysis Access.The open urology & nephrology journal · 2014Article
- Low-intensity pulsed ultrasound accelerates tooth movement via activation of the BMP-2 signaling pathway.PloS one · 2013Article
- A link between smooth muscle cell death and extracellular matrix degradation during vascular atrophy.Journal of vascular surgery · 2011Article
- Cell death-associated ADAMTS4 and versican degradation in vascular tissue.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2009Article
- Hemodynamic forces, vascular oxidative stress, and regulation of BMP-2/4 expression.Antioxidants & redox signaling · 2009Review
- Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice.American journal of physiology. Heart and circulatory physiology · 2008Article
- Target accessibility and signal specificity in live-cell detection of BMP-4 mRNA using molecular beacons.Nucleic acids research · 2008Article
- Induction of vascular atrophy as a novel approach to treating restenosis. A review.Journal of vascular surgery · 2008Review
- Endothelial Bmp4 is induced during arterial remodeling: effects on smooth muscle cell migration and proliferation.The Journal of surgical research · 2008Article
- A unique preovulatory expression pattern plays a key role in the physiological functions of BMP-15 in the mouse.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
objectivePlacement in baboons of a distal femoral arteriovenous fistula increases shear stress through aortoiliac polytetrafluoroethylene (PTFE) grafts and induces regression of a preformed neointima. Atrophy of the neointima might be controlled by shear stress-induced genes, including the bone morphogenetic proteins (BMPs). We have investigated the expression and function of BMPs 2, 4, and 5 in the graft neointima and in cultured baboon smooth muscle cells (SMCs).
methodsBaboons received bilateral aortoiliac PTFE grafts and 8 weeks later, a unilateral femoral arteriovenous fistula.
resultsQuantitative polymerase chain reaction showed that high shear stress increased BMP2, 4, and 5 messenger RNA (mRNA) in graft intima between 1 and 7 days, while noggin (a BMP inhibitor) mRNA was decreased. BMP4 most potently (60% inhibition) inhibited platelet-derived growth factor-stimulated SMC proliferation compared with BMP2 and BMP5 (31% and 26%, respectively). BMP4 also increased SMC death by 190% +/- 10%. Noggin reversed the antiproliferative and proapoptotic effects of BMP4. Finally, Western blotting confirmed BMP4 protein upregulation by high shear stress at 4 days. BMP4 expression demonstrated by in situ hybridization was confined to endothelial cells.
conclusionsIncreased BMPs (particularly BMP4) coupled with decreased noggin may promote high shear stress-mediated graft neointimal atrophy by inhibiting SMC proliferation and increasing SMC death.
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