ReviewClinical and experimental immunology2006
The natural killer T lymphocyte: a player in the complex regulation of autoimmune diabetes in non-obese diabetic mice.
Review in Clinical and experimental immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 51 citations in OpenAlex.
- Effect of Early-life Gut Mucosal Compromise on Disease Progression in NOD Mice.Comparative medicine · 2017Article
- Article
- Disposal of iNKT cell deficiency and an increase in expression of SLAM signaling factors characterizes sarcoidosis remission: a 4-year longitudinal study.Respiratory research · 2014Article
- Different subsets of natural killer T cells may vary in their roles in health and disease.Immunology · 2014Review
- Antigen-dependent versus -independent activation of invariant NKT cells during infection.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Consumption of acidic water alters the gut microbiome and decreases the risk of diabetes in NOD mice.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2014Article
- NKT Cell Subsets Can Exert Opposing Effects in Autoimmunity, Tumor Surveillance and Inflammation.Current immunology reviews · 2012Article
- Suppression of dendritic cell activation by diabetes autoantigens linked to the cholera toxin B subunit.Immunobiology · 2011Article
- Cross-talk between cd1d-restricted nkt cells and γδ cells in t regulatory cell response.Virology journal · 2011Review
- Endogenous collagen peptide activation of CD1d-restricted NKT cells ameliorates tissue-specific inflammation in mice.The Journal of clinical investigation · 2011Article
- Natural killer T cells: innate lymphocytes positioned as a bridge between acute and chronic inflammation?Microbes and infection · 2010Review
- γδ T lymphocytes kill T regulatory cells through CD1d.Immunology · 2010Article
- Autoantigens plus interleukin-10 suppress diabetes autoimmunity.Diabetes technology & therapeutics · 2010Article
- Prevention of diabetes in NOD mice by repeated exposures to a contact allergen inducing a sub-clinical dermatitis.PloS one · 2010Article
- Human NKT cells promote monocyte differentiation into suppressive myeloid antigen-presenting cells.Journal of leukocyte biology · 2009Article
- Multiple tissue-specific isoforms of sulfatide activate CD1d-restricted type II NKT cells.European journal of immunology · 2009Article
- Graft failure IV. Immunologic mechanisms of corneal transplant rejection.International ophthalmology · 2008Review
- Association of interferon-gamma and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes.Clinical and experimental immunology · 2006Article
- Failure of alpha-galactosylceramide to prevent diabetes in virus-inducible models of type 1 diabetes in the rat.In vivo (Athens, Greece)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Manipulation of the immune response to specifically prevent autoaggression requires an understanding of the complex interactions that occur during the pathogenesis of autoimmunity. Much attention has been paid to conventional T lymphocytes recognizing peptide antigens presented by classical major histocompatibility complex (MHC) class I and II molecules, as key players in the destructive autoreactive process. A pivotal role for different types of regulatory T lymphocytes in modulating the development of disease is also well established. Lately, CD1d-restricted natural killer T (NKT) lymphocytes have been the subject of intense investigation because of their ability to regulate a diversity of immune responses. The non-classical antigen presenting molecule CD1d presents lipids and glycolipids to this highly specialized subset of T lymphocytes found in both humans and mice. From experimental models of autoimmunity, evidence is accumulating that NKT cells can protect from disease. One of the best studied is the murine type 1 diabetes model, the non-obese diabetic (NOD) mouse. While the NKT cell population was first recognized to be deficient in NOD mice, augmenting NKT cell activity has been shown to suppress the development of autoimmune disease in this strain. The mechanism by which CD1d-restricted T cells exert this function is still described incompletely, but investigations in NOD mice are starting to unravel specific effects of NKT cell regulation. This review focuses on the role of CD1d-restricted NKT cells in the control of autoimmune diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.