ArticleMuscle & nerve2006
Dose-dependent separation of the hypertrophic and myotoxic effects of the beta(2)-adrenergic receptor agonist clenbuterol in rat striated muscles.
Article in Muscle & nerve, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Impact of Vasoactive Medications on ICU-Acquired Weakness in Mechanically Ventilated Patients.Chest · 2018Trial
- BetaThe Journal of physiology · 2018Trial
- Chronic βThe Journal of physiology · 2018Trial
- One-step fabrication of 3D-aligned human skeletal muscle tissue and measurement of contractile force for preclinical drug testing.Materials today. Bio · 2025Article
- Muscle hypertrophic effect of inhaled betaThe Journal of physiology · 2022Article
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- Cation dyshomeostasis and cardiomyocyte necrosis: the Fleckenstein hypothesis revisited.European heart journal · 2011Article
- Randomized, double-blind, and placebo-controlled trial of clenbuterol in denervated muscle atrophy.ISRN pharmaceutics · 2011Article
- Muscle plasticity and β₂-adrenergic receptors: adaptive responses of β₂-adrenergic receptor expression to muscle hypertrophy and atrophy.Journal of biomedicine & biotechnology · 2011Review
- Adaptive effects of the beta2-agonist clenbuterol on expression of beta2-adrenoceptor mRNA in rat fast-twitch fiber-rich muscles.The journal of physiological sciences : JPS · 2010Article
- Effects of clenbuterol, a β₂-adrenergic agonist, on sizes of masseter, temporalis, digastric, and tongue muscles.The open dentistry journal · 2009Article
- Beta2 adrenergic agonist, clenbuterol, enhances working memory performance in aging animals.Neurobiology of aging · 2008Article
- Anabolic effects of a non-myotoxic dose of the beta2-adrenergic receptor agonist clenbuterol on rat plantaris muscle.Muscle & nerve · 2007Article
- Relative myotoxic and haemodynamic effects of the beta-agonists fenoterol and clenbuterol measured in conscious unrestrained rats.Experimental physiology · 2006Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Muscle growth in response to large doses (milligrams per kilogram) of beta(2)-adrenergic receptor agonists has been reported consistently. However, such doses may also induce myocyte death in the heart and skeletal muscles and hence may not be safe doses for humans. We report the hypertrophic and myotoxic effects of different doses of clenbuterol. Rats were infused with clenbuterol (range, 1 microg to 1 mg.kg(-1)) for 14 days. Muscle protein content, myofiber cross-sectional area, and myocyte death were then investigated. Infusions of >or=10 microg.kg(-1).d(-1) of clenbuterol significantly (P<0.05) increased the protein content of the heart (12%-15%), soleus (12%), plantaris (18%-29%), and tibialis anterior (11%-22%) muscles, with concomitant myofiber hypertrophy. Larger doses (100 microg or 1 mg) induced significant (P<0.05) myocyte death in the soleus (peak 0.2+/-0.1% apoptosis), diaphragm (peak 0.15+/-0.1% apoptosis), and plantaris (peak 0.3+/-0.05% necrosis), and significantly increased the area fraction of collagen in the myocardium. These data show that the low dose of 10 microg.kg(-1).d(-1) can be used in rats to investigate the anabolic effects of clenbuterol in the absence of myocyte death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.