ArticleMolecular and cellular biochemistry2006
ACBP--a PPAR and SREBP modulated housekeeping gene.
Article in Molecular and cellular biochemistry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Hindbrain octadecaneuropeptide gliotransmission as a therapeutic target for energy balance control without nausea or emesis.Science translational medicine · 2025Article
- Atlas of expression of acyl CoA binding protein/diazepam binding inhibitor (ACBP/DBI) in human and mouse.Cell death & disease · 2025Article
- Proteomics-Based Investigation of Different Live Prey Administered to Freshwater Dark Sleeper (Metabolites · 2024Article
- Benzodiazepines compromise the outcome of cancer immunotherapy.Oncoimmunology · 2024Article
- Probiotic Fermented Feed Alleviates Liver Fat Deposition in Shaoxing DucksFrontiers in microbiology · 2022Article
- Elevated plasma levels of the appetite-stimulator ACBP/DBI in fasting and obese subjects.Cell stress · 2021Article
- Expression of acyl-CoA-binding protein 5 from Rhodnius prolixus and its inhibition by RNA interference.PloS one · 2020Article
- Acyl-CoA-Binding Protein ACBP1 Modulates Sterol Synthesis during Embryogenesis.Plant physiology · 2017Article
- Compromised epidermal barrier stimulates Harderian gland activity and hypertrophy in ACBP-/- mice.Journal of lipid research · 2015Article
- Lung cancer diagnosis from proteomic analysis of preinvasive lesions.Cancer research · 2011Article
- Specific regulation of low-abundance transcript variants encoding human Acyl-CoA binding protein (ACBP) isoforms.Journal of cellular and molecular medicine · 2011Article
- Disruption of the acyl-CoA-binding protein gene delays hepatic adaptation to metabolic changes at weaning.The Journal of biological chemistry · 2011Article
- Acyl-CoA binding protein gene ablation induces pre-implantation embryonic lethality in mice.Lipids · 2010Article
- Downregulation of PPARs and SREBP by acyl-CoA-binding protein overexpression in transgenic rats.Pflugers Archiv : European journal of physiology · 2008Article
- Structural and functional characterization of a new recombinant histidine-tagged acyl coenzyme A binding protein (ACBP) from mouse.Protein expression and purification · 2008Article
- Evaluation and integration of 49 genome-wide experiments and the prediction of previously unknown obesity-related genes.Bioinformatics (Oxford, England) · 2007Article
- Estrogen receptor alpha regulates expression of the breast cancer 1 associated ring domain 1 (BARD1) gene through intronic DNA sequence.Molecular and cellular endocrinology · 2007Article
- Position and distance specificity are important determinants of cis-regulatory motifs in addition to evolutionary conservation.Nucleic acids research · 2007Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The acyl-CoA binding protein (ACBP) is a 10 kD intracellular lipid binding protein that binds and transports acyl-CoA esters. The protein is expressed in most cell types at low levels; however, expression differs markedly between different cell types with expression being particularly high in e.g. cells with a high turnover of fatty acids. We show here that the relatively high basal promoter activity of the rat ACBP gene in fibroblasts and hepatoma cells relies on sequences between -331 to -182 and on the Sp1 and NF-Y sites at -172 and -143, respectively. The basal transcription is modulated by members of the PPAR and SREBP families. In adipocytes, PPARgamma is in part responsible for the induction during adipocyte differentiation, but other transcription factors appear to play a role as well. In hepatocytes, SREBP-1c is the main regulator of ACBP in response to changes in insulin levels during fasting/refeeding. PPARalpha counteracts this effect by stimulating ACBP expression during fasting. In addition, PPARalpha mediates the induction of ACBP expression in response to peroxisome proliferators. PPARalpha and PPARgamma do not require sequences upstream of -182 for transactivation; however, SREBP-1c requires the synergistic action of sequences in intron 1 for transactivation of the ACBP promoter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.