ArticleCell death and differentiation2006
Two distinct signaling pathways regulate peroxynitrite-induced apoptosis in PC12 cells.
Article in Cell death and differentiation, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 79 citations in OpenAlex.
- Mechanism of Action and Anti-Inflammatory Activity of Pestalotioquinol A, a Fungus-Derived Cytoprotective Compound.ACS omega · 2025Article
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- C5a Induces Inflammatory Signaling and Apoptosis in PC12 Cells through C5aR-Dependent Signaling: A Potential Mechanism for Adrenal Damage in Sepsis.International journal of molecular sciences · 2024Article
- Oxidation of Aldehydes Used as Food Additives by Peroxynitrite.Antioxidants (Basel, Switzerland) · 2023Article
- Peroxynitrite nitration of Tyr 56 in Hsp90 induces PC12 cell death through P2X7R-dependent PTEN activation.Redox biology · 2022Article
- Peroxynitrite supports a metabolic reprogramming in merlin-deficient Schwann cells and promotes cell survival.The Journal of biological chemistry · 2019Article
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- The NOX1 isoform of NADPH oxidase is involved in dysfunction of liver sinusoids in nonalcoholic fatty liver disease.Free radical biology & medicine · 2018Article
- Tumor Killing by CD4Frontiers in immunology · 2018Article
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- Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11bCell death and differentiation · 2017Article
- Peroxynitrite is Involved in the Apoptotic Death of Cultured Cerebellar Granule Neurons Induced by Staurosporine, but not by Potassium Deprivation.Neurochemical research · 2016Article
- Nitration of Hsp90 on Tyrosine 33 Regulates Mitochondrial Metabolism.The Journal of biological chemistry · 2015Article
- Reactive nitrogen species in cellular signaling.Experimental biology and medicine (Maywood, N.J.) · 2015Review
- Modification of HSP proteins and Ca2+ are responsible for the NO-derived peroxynitrite mediated neurological damage in PC12 cell.International journal of clinical and experimental pathology · 2015Article
- Nitration of Hsp90 induces cell death.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Temporal patterns of tyrosine nitration in embryo heart development.Free radical biology & medicine · 2013Article
- Gelam honey scavenges peroxynitrite during the immune response.International journal of molecular sciences · 2012Article
- Roles of reactive oxygen and nitrogen species in pain.Free radical biology & medicine · 2011Review
- Inhibition of Human Cervical Cancer Cell Growth by Ethanolic Extract of Boerhaavia diffusa Linn. (Punarnava) Root.Evidence-based complementary and alternative medicine : eCAM · 2011Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The mechanisms of peroxynitrite-induced apoptosis are not fully understood. We report here that peroxynitrite-induced apoptosis of PC12 cells requires the simultaneous activation of p38 and JNK MAP kinase, which in turn activates the intrinsic apoptotic pathway, as evidenced by Bax translocation to the mitochondria, cytochrome c release to the cytoplasm and activation of caspases, leading to cell death. Peroxynitrite induces inactivation of the Akt pathway. Furthermore, overexpression of constitutively active Akt inhibits both peroxynitrite-induced Bax translocation and cell death. Peroxynitrite-induced death was prevented by overexpression of Bcl-2 and by cyclosporin A, implicating the involvement of the intrinsic apoptotic pathway. Selective inhibition of mixed lineage kinase (MLK), p38 or JNK does not attenuate the decrease in Akt phosphorylation showing that inactivation of the Akt pathway occurs independently of the MLK/MAPK pathway. Together, these results reveal that peroxynitrite-induced activation of the intrinsic apoptotic pathway involves interactions with the MLK/MAPK and Akt signaling pathways.
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