ArticleCarcinogenesis2006
Analysis of epidemiological cohort data on smoking effects and lung cancer with a multi-stage cancer model.
Article in Carcinogenesis, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Calculating preventable risk fractions for exposure-reducing interventions.Global epidemiology · 2025Article
- Analysis of Lung Cancer Incidence in Non-Hispanic Black and White Americans using a Multistage Carcinogenesis Model.Cancer causes & control : CCC · 2025Article
- Contribution of smoking, disease history, and survival to lung cancer disparities in Black individuals.Journal of the National Cancer Institute. Monographs · 2023Article
- Association of the age at smoking initiation and cessation on all-cause and cause-specific mortality: The Japan Collaborative Cohort Study.Nagoya journal of medical science · 2023Article
- Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach.Oral oncology · 2019Article
- Alzheimer's disease as a multistage process: an analysis from a population-based cohort study.Aging · 2019Article
- Small suitability of the DLEC1, MLH1 and TUSC4 mRNA expression analysis as potential prognostic or differentiating markers for NSCLC patients in the Polish population.Journal of genetics · 2017Article
- Beyond two-stage models for lung carcinogenesis in the Mayak workers: implications for plutonium risk.PloS one · 2015Article
- Article
- Dose-responses from multi-model inference for the non-cancer disease mortality of atomic bomb survivors.Radiation and environmental biophysics · 2012Article
- Impact of reduced tobacco smoking on lung cancer mortality in the United States during 1975-2000.Journal of the National Cancer Institute · 2012Article
- Association of XRCC3 and XPD751 SNP with efficacy of platinum-based chemotherapy in advanced NSCLC patients.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2012Article
- Cigarette Smoking and Lung Cancer: Pediatric Roots.Lung cancer international · 2012Review
- Tumor heterogeneity: mechanisms and bases for a reliable application of molecular marker design.International journal of molecular sciences · 2012Review
- Article
- Models of carcinogenesis: an overview.Carcinogenesis · 2010Review
- Breast cancer risk from different mammography screening practices.Radiation research · 2010Article
- Cell selection as driving force in lung and colon carcinogenesis.Cancer research · 2010Article
- Estimation of the effects of smoking and DNA repair capacity on coefficients of a carcinogenesis model for lung cancer.International journal of cancer · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
Abstract
A stochastic two-stage cancer model is used to analyse the relation between lung cancer and cigarette smoking. The model contains the main rate-limiting stages of carcinogenesis, which include initiation, promotion (clonal expansion of initiated cells), malignant transformation and a lag time for tumour formation. Various data sets were used to test the model. These include the data of a large prospective collaborative project carried out in 10 different European countries, the European Prospective Investigation into Cancer and Nutrition (EPIC). This new data set has not been modelled before. The model is also tested on other published data from CPS-II (Cancer Prevention Study II) of the American Cancer Society and the British doctors' study. The analyses indicate that the EPIC data are best described with smoking dependence on the rates of malignant transformation and clonal expansion. With increasing smoking rates, saturation effects in the two exposure rate-dependent model parameters were observed. The results find confirmation in the biological literature, where both mutational effects and promotional effects of cigarette smoke are documented.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.