ReviewRetrovirology2006
Anti-viral RNA silencing: do we look like plants?
Review in Retrovirology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 56 citations in OpenAlex.
- Meta-transcriptomic analysis reveals the geographical expansion of known sugarbeet-infecting viruses and the occurrence of a novel virus in sugarbeet in the United States.Frontiers in plant science · 2024Article
- Review
- Transcellular chaperone signaling: an organismal strategy for integrated cell stress responses.The Journal of experimental biology · 2014Review
- Article
- Characterization of the RNA silencing suppression activity of the Ebola virus VP35 protein in plants and mammalian cells.Journal of virology · 2012Article
- Retroviral GAG proteins recruit AGO2 on viral RNAs without affecting RNA accumulation and translation.Nucleic acids research · 2012Article
- A systematic approach to virus-virus interactions.Virus research · 2010Review
- Herpes simplex virus type 1 suppresses RNA-induced gene silencing in mammalian cells.Journal of virology · 2009Article
- Functional analysis of the cathepsin-like cysteine protease genes in adult Brugia malayi using RNA interference.PLoS neglected tropical diseases · 2009Article
- H-index, mentoring-index, highly-cited and highly-accessed: how to evaluate scientists?Retrovirology · 2008Article
- Roles of microRNA in plant defense and virus offense interaction.Plant cell reports · 2008Review
- Improving model predictions for RNA interference activities that use support vector machine regression by combining and filtering features.BMC bioinformatics · 2007Article
- Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral production.Journal of virology · 2007Article
- The silent defense: micro-RNA directed defense against HIV-1 replication.Retrovirology · 2007Article
- RNAi therapy for HIV infection: principles and practicalities.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2007Review
- HIV-1 Tat interaction with Dicer: requirement for RNA.Retrovirology · 2006Article
- Human Immunodeficiency Virus-Type 1 LTR DNA contains an intrinsic gene producing antisense RNA and protein products.Retrovirology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The anti-viral function of RNA silencing was first discovered in plants as a natural manifestation of the artificial 'co-suppression', which refers to the extinction of endogenous gene induced by homologous transgene. Because silencing components are conserved among most, if not all, eukaryotes, the question rapidly arose as to determine whether this process fulfils anti-viral functions in animals, such as insects and mammals. It appears that, whereas the anti-viral process seems to be similarly conserved from plants to insects, even in worms, RNA silencing does influence the replication of mammalian viruses but in a particular mode: micro(mi)RNAs, endogenous small RNAs naturally implicated in translational control, rather than virus-derived small interfering (si)RNAs like in other organisms, are involved. In fact, these recent studies even suggest that RNA silencing may be beneficial for viral replication. Accordingly, several large DNA mammalian viruses have been shown to encode their own miRNAs. Here, we summarize the seminal studies that have implicated RNA silencing in viral infection and compare the different eukaryotic responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.