ArticleJournal of molecular evolution2006
Adaptive evolution and recombination of Rickettsia antigens.
Article in Journal of molecular evolution, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Bridging historical antigenic profiling and whole-genome taxonomy inScientific reviews · 2026Review
- Metagenome diversity illuminates origins of pathogen effectors.bioRxiv : the preprint server for biology · 2023Article
- Molecular Characterization by Multilocus Sequence Typing and Diversity Analysis ofVector borne and zoonotic diseases (Larchmont, N.Y.) · 2022Article
- Article
- Uniparental Inheritance Promotes Adaptive Evolution in Cytoplasmic Genomes.Molecular biology and evolution · 2017Article
- Comparative genome sequencing of Rickettsia rickettsii strains that differ in virulence.Infection and immunity · 2015Article
- Secretome of obligate intracellular Rickettsia.FEMS microbiology reviews · 2015Review
- The role of selection in shaping diversity of natural M. tuberculosis populations.PLoS pathogens · 2013Article
- Surface proteome analysis and characterization of surface cell antigen (Sca) or autotransporter family of Rickettsia typhi.PLoS pathogens · 2012Article
- Comparative analysis of Wolbachia surface protein in D. melanoagster, A. tabida and B. malayi.Bioinformation · 2012Article
- Accelerated microevolution in an outer membrane protein (OMP) of the intracellular bacteria Wolbachia.BMC evolutionary biology · 2010Article
- Genome wide evolutionary analyses reveal serotype specific patterns of positive selection in selected Salmonella serotypes.BMC evolutionary biology · 2009Article
- Evolution and diversity of Rickettsia bacteria.BMC biology · 2009Article
- Evidence of extensive homologous recombination in the core genome of rickettsia.Comparative and functional genomics · 2009Article
- Symbiont-mediated protection.Proceedings. Biological sciences · 2008Review
- Article
- Article
- Lateral gene transfer between obligate intracellular bacteria: evidence from the Rickettsia massiliae genome.Genome research · 2007Article
- Evolution of Chlamydia trachomatis diversity occurs by widespread interstrain recombination involving hotspots.Genome research · 2007Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The genus Rickettsia consists of intracellular bacteria that cause a variety of arthropod vectored human diseases. I have examined the evolutionary processes that are generating variation in antigens that are potential vaccine candidates. The surface proteins rOmpA and rOmpB are subject to intense positive natural selection, causing rapid diversification of their amino acid sequences between species. The positively selected amino acids were mapped and cluster together in regions that may indicate the location of functionally important regions such as epitopes. In contrast to the rOmp antigens, there is no evidence of positive selection on the intracytoplasmic antigen PS120 despite low selective constraints on this gene. All three genes showed evidence of recombination between species, and certain sequences are clear chimeras of two parental sequences. However, recombination has been sufficiently infrequent that the phylogenies of the three genes are similar, although not identical.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.