ArticleEuropean journal of clinical pharmacology2006
Increasing use of medicines in elderly persons: a five-year follow-up of the Kuopio 75+Study.
Article in European journal of clinical pharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 148 citations in OpenAlex.
- Temporal Trends in Analgesic Use in Long-Term Care Facilities: A Systematic Review of International Prescribing.Journal of the American Geriatrics Society · 2018Pooled it
- Risk Factors for Malnutrition in Older Adults: A Systematic Review of the Literature Based on Longitudinal Data.Advances in nutrition (Bethesda, Md.) · 2016Pooled it
- Trial
- Melatonin for sedative withdrawal in older patients with primary insomnia: a randomized double-blind placebo-controlled trial.British journal of clinical pharmacology · 2014Trial
- Effects of medication assessment as part of a comprehensive geriatric assessment on drug use over a 1-year period: a population-based intervention study.Drugs & aging · 2010Trial
- Sedative load and mortality among residents of long-term care facilities: a prospective cohort study.Drugs & aging · 2009Trial
- Polypharmacy in Polish Older Adult Population-A Cross-Sectional Study: Results of the PolSenior Project.International journal of environmental research and public health · 2022Article
- A cross-sectional study of psychotropic drug use in the elderly: Consuming patterns, risk factors and potentially inappropriate use.European journal of hospital pharmacy : science and practice · 2021Review
- Purchases of medicines among community-dwelling older people: comparing people in the last 2 years of life and those who lived at least 2 years longer.European journal of ageing · 2020Article
- Potentially Inappropriate Prescribing and Potential Clinically Significant Drug-Drug Interactions in Older Outpatients: Is There Any Association?Medicina (Kaunas, Lithuania) · 2019Article
- Risk factors for polypharmacy in older adults in a primary care setting: a cross-sectional study.Clinical interventions in aging · 2018Article
- The epidemiology of polypharmacy in older adults: register-based prospective cohort study.Clinical epidemiology · 2018Article
- Drug utilization patterns among elderly hospitalized patients on poly-pharmacy in Punjab, Pakistan.Journal of pharmaceutical policy and practice · 2017Article
- Changes in Drug Use and Polypharmacy After the Age of 90: A Longitudinal Study of the Danish 1905 Cohort.Journal of the American Geriatrics Society · 2017Article
- Potentially severe drug-drug interactions among older people and associations in assisted living facilities in Finland: a cross-sectional study.Scandinavian journal of primary health care · 2016Article
- Polypharmacy in the terminal stage of cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Article
- Do newly marketed generic medicines expand markets using descriptive time series analysis and mixed logit models? Korea as an exemplar and its implications.BMC health services research · 2016Article
- The impact of dementia on drug costs in older people: results from the SNAC study.BMC neurology · 2016Article
- Sufficient competence in community elderly care? Results from a competence measurement of nursing staff.BMC nursing · 2016Article
- Social Pharmacy and Clinical Pharmacy-Joining Forces.Pharmacy (Basel, Switzerland) · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to describe the changes in medicine use, polypharmacy and excessive polypharmacy between 1998 and 2003 among a cohort of elderly Finns.
methodsFor this prospective follow-up study, a random sample of 700 participants aged >or=75 years was drawn from the City of Kuopio, Finland. Of them, 601 participated in the study at baseline in 1998. The changes in medicine use among the survivors (n=339), who were re-examined in 2003, were recorded and are described here. Statistical significance of changes in medicine use was evaluated by Student's paired-samples and independent-samples t-test and Fisher's exact test.
resultsFrom 1998 to 2003, the mean number of medicines in use per individual increased from 6.3 to 7.5 (p<0.001). The prevalence of polypharmacy (>5 medicines in use) increased from 54% to 67% and excessive polypharmacy (>or=10 medicines in use) from 19% to 28%. The increase was due to increased use of regularly taken medicines, whereas the use of medicines taken as needed decreased during the follow-up in both sexes. At the time of follow-up survey, persons in institutional care used significantly more medicines (10.9) than community-dwelling elderly persons (7.0) (p<0.001). Central nervous system medicines and cardiovascular medicines were the most commonly used medicines in both years.
conclusionThe number of medicines and the prevalence of polypharmacy and excessive polypharmacy increases with advancing age. In order to avoid possible harmful effects and to optimize medication it is necessary to assess the medication regimen at regular intervals.
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