ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Sodium currents activate without a Hodgkin-and-Huxley-type delay in central mammalian neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 76 citations in OpenAlex.
- Article
- Long-Term Inactivation of Sodium Channels as a Mechanism of Adaptation in CA1 Pyramidal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- Action potential propagation and synchronisation in myelinated axons.PLoS computational biology · 2019Article
- Axonal Computations.Frontiers in cellular neuroscience · 2019Review
- Noninvasive extraction of microsecond-scale dynamics from human motor cortex.Human brain mapping · 2018Article
- Voltage-Gated Sodium Channels in Neocortical Pyramidal Neurons Display Cole-Moore Activation Kinetics.Frontiers in cellular neuroscience · 2018Article
- Encoding of High Frequencies Improves with Maturation of Action Potential Generation in Cultured Neocortical Neurons.Frontiers in cellular neuroscience · 2017Article
- Spikelets in Pyramidal Neurons: Action Potentials Initiated in the Axon Initial Segment That Do Not Activate the Soma.PLoS computational biology · 2017Article
- Excitability tuning of axons in the central nervous system.The journal of physiological sciences : JPS · 2016Review
- Article
- Action potential initiation in a multi-compartmental model with cooperatively gating Na channels in the axon initial segment.Journal of computational neuroscience · 2015Article
- What is the most realistic single-compartment model of spike initiation?PLoS computational biology · 2015Review
- Density of voltage-gated potassium channels is a bifurcation parameter in pyramidal neurons.Journal of neurophysiology · 2015Article
- Relating ion channel expression, bifurcation structure, and diverse firing patterns in a model of an identified motor neuron.Journal of computational neuroscience · 2013Article
- Fast computations in cortical ensembles require rapid initiation of action potentials.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Sharpness of spike initiation in neurons explained by compartmentalization.PLoS computational biology · 2013Article
- A small fraction of strongly cooperative sodium channels boosts neuronal encoding of high frequencies.PloS one · 2012Article
- Article
- Impact of fast sodium channel inactivation on spike threshold dynamics and synaptic integration.PLoS computational biology · 2011Article
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Authors and funding
2 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Hodgkin and Huxley established that sodium currents in the squid giant axons activate after a delay, which is explained by the model of a channel with three identical independent gates that all have to open before the channel can pass current (the HH model). It is assumed that this model can adequately describe the sodium current activation time course in all mammalian central neurons, although there is no experimental evidence to support such a conjecture. We performed high temporal resolution studies of sodium currents gating in three types of central neurons. The results show that, within the tested voltage range from -55 to -35 mV, in all of these neurons, the activation time course of the current could be fit, after a brief delay, with a monoexponential function. The duration of delay from the start of the voltage command to the start of the extrapolated monoexponential fit was much smaller than predicted by the HH model. For example, in prefrontal cortex pyramidal neurons, at -46 mV and 12 degrees C, the observed average delay was 140 micros versus the 740 micros predicted by the two-gate HH model and the 1180 micros predicted by the three-gate HH model. These results can be explained by a model with two closed states and one open state. In this model, the transition between two closed states is approximately five times faster than the transition between the second closed state and the open state. This model captures all major properties of the sodium current activation. In addition, the proposed model reproduces the observed action potential shape more accurately than the traditional HH model.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.