ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Neuromuscular synapse formation in mice lacking motor neuron- and skeletal muscle-derived Neuregulin-1.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 92 citations in OpenAlex.
- Differential evaluation of neuromuscular injuries to understand re-innervation at the neuromuscular junction.Experimental neurology · 2024Article
- Building, Breaking, and Repairing Neuromuscular Synapses.Cold Spring Harbor perspectives in biology · 2024Review
- Boosting neuregulin 1 type-III expression hastens SMA motor axon maturation.Acta neuropathologica communications · 2023Article
- Article
- Extracellular signal-regulated kinases 1 and 2 regulate neuromuscular junction and myofiber phenotypes in mammalian skeletal muscle.Neuroscience letters · 2020Review
- Nerve, Muscle, and Synaptogenesis.Cells · 2019Review
- Vezatin is required for the maturation of the neuromuscular synapse.Molecular biology of the cell · 2019Article
- MACF1 links Rapsyn to microtubule- and actin-binding proteins to maintain neuromuscular synapses.The Journal of cell biology · 2019Article
- Specific effects of neuregulin-1β on the communication between DRG neurons and skeletal muscle cells in vitro.Journal of muscle research and cell motility · 2018Article
- Preserving neuromuscular synapses in ALS by stimulating MuSK with a therapeutic agonist antibody.eLife · 2018Article
- Fundamental Molecules and Mechanisms for Forming and Maintaining Neuromuscular Synapses.International journal of molecular sciences · 2018Review
- The Scaffolding Protein, Grb2-associated Binder-1, in Skeletal Muscles and Terminal Schwann Cells Regulates Postnatal Neuromuscular Synapse Maturation.Experimental neurobiology · 2017Article
- Neuregulin1 fine-tunes pre-, post-, and perisynaptic neuromuscular junction development.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Article
- Group I Paks Promote Skeletal Myoblast Differentiation In Vivo and In Vitro.Molecular and cellular biology · 2017Article
- Schwann Cells in Neuromuscular Junction Formation and Maintenance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Diverging roles for Lrp4 and Wnt signaling in neuromuscular synapse development during evolution.Genes & development · 2016Article
- Neuregulin1 displayed on motor axons regulates terminal Schwann cell-mediated synapse elimination at developing neuromuscular junctions.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Neurological dysfunctions associated with altered BACE1-dependent Neuregulin-1 signaling.Journal of neurochemistry · 2016Review
- Expression and function of Neuregulin 1 and its signaling system ERBB2/3 in the enteric nervous system.Frontiers in cellular neuroscience · 2015Article
- An explant muscle model to examine the refinement of the synaptic landscape.Journal of neuroscience methods · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The localization of acetylcholine receptors (AChRs) to the vertebrate neuromuscular junction is mediated, in part, through selective transcription of AChR subunit genes in myofiber subsynaptic nuclei. Agrin and the muscle-specific receptor tyrosine kinase, MuSK, have critical roles in synapse-specific transcription, because AChR genes are expressed uniformly in mice lacking either agrin or MuSK. Several lines of evidence suggest that agrin and MuSK stimulate synapse-specific transcription indirectly by regulating the distribution of other cell surface ligands, which stimulate a pathway for synapse-specific gene expression. This putative secondary signal for directing AChR gene expression to synapses is not known, but Neuregulin-1 (Nrg-1), primarily based on its presence at synapses and its ability to induce AChR gene expression in vitro, has been considered a good candidate. To study the role of Nrg-1 at neuromuscular synapses, we inactivated nrg-1 in motor neurons, skeletal muscle, or both cell types, using mice that express Cre recombinase selectively in developing motor neurons or in developing skeletal myofibers. We find that AChRs are clustered at synapses and that synapse-specific transcription is normal in mice lacking Nrg-1 in motor neurons, myofibers, or both cell types. These data indicate that Nrg-1 is dispensable for clustering AChRs and activating AChR genes in subsynaptic nuclei during development and suggest that these aspects of postsynaptic differentiation are dependent on Agrin/MuSK signaling without a requirement for a secondary signal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.