ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
GABAergic signaling at mossy fiber synapses in neonatal rat hippocampus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 91 citations in OpenAlex.
- Regulation of GABAergic neurotransmission by purinergic receptors in brain physiology and disease.Purinergic signalling · 2025Review
- Impaired synaptic plasticity in an animal model of autism exhibiting early hippocampal GABAergic-BDNF/TrkB signaling alterations.iScience · 2023Article
- Adult-born dentate granule cells promote hippocampal population sparsity.Nature neuroscience · 2022Article
- Dysregulation of GABAergic Signaling in Neurodevelomental Disorders: Targeting Cation-Chloride Co-transporters to Re-establish a Proper E/I Balance.Frontiers in cellular neuroscience · 2021Review
- Immature Dentate Granule Cells Require Ntrk2/Trkb for the Formation of Functional Hippocampal Circuitry.iScience · 2020Article
- Spike-Related Electrophysiological Identification of Cultured Hippocampal Excitatory and Inhibitory Neurons.Molecular neurobiology · 2019Article
- [Effects of embryonic lead exposure on motor function and balance ability in offspring rats and possible mechanisms].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Article
- Target-Dependent Compartmentalization of the Corelease of Glutamate and GABA from the Mossy Fibers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Early Correlated Network Activity in the Hippocampus: Its Putative Role in Shaping Neuronal Circuits.Frontiers in cellular neuroscience · 2017Review
- Few, Activity-Dependent, and Ubiquitous VGLUT1/VGAT Terminals in Rat and Mouse Brain.Frontiers in cellular neuroscience · 2017Article
- Article
- Co-existence of Functionally Different Vesicular Neurotransmitter Transporters.Frontiers in synaptic neuroscience · 2016Review
- Extracellular proteolysis in structural and functional plasticity of mossy fiber synapses in hippocampus.Frontiers in cellular neuroscience · 2015Review
- Mood regulation. GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment.Science (New York, N.Y.) · 2014Article
- Dynamic regulation of neurotransmitter specification: relevance to nervous system homeostasis.Neuropharmacology · 2014Review
- Electrophysiological characterization of granule cells in the dentate gyrus immediately after birth.Frontiers in cellular neuroscience · 2014Article
- Mixed neurotransmission in the hippocampal mossy fibers.Frontiers in cellular neuroscience · 2013Review
- PrPC controls via protein kinase A the direction of synaptic plasticity in the immature hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Is GABA co-released with glutamate from hippocampal mossy fiber terminals?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Molecular and functional characterization of GAD67-expressing, newborn granule cells in mouse dentate gyrus.Frontiers in neural circuits · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the adult rat hippocampus, granule cell mossy fibers (MFs) form excitatory glutamatergic synapses with CA3 principal cells and local inhibitory interneurons. However, evidence has been provided that, in young animals and after seizures, the same fibers can release in addition to glutamate GABA. Here we show that, during the first postnatal week, stimulation of granule cells in the dentate gyrus gave rise to monosynaptic GABAA-mediated responses in principal cells and in interneurons. These synapses were indeed made by MFs because they exhibited strong paired-pulse facilitation, high sensitivity to the metabotropic glutamate receptor agonist l-AP-4, and short-term frequency-dependent facilitation. MF responses were potentiated by blocking the plasma membrane GABA transporter GAT-1 with NO-711 or by allosterically modulating GABAA receptors with flurazepam. Chemical stimulation of granule cell dendrites with glutamate induced barrages of GABAA-mediated postsynaptic currents into target neurons. Furthermore, immunocytochemical experiments demonstrated colocalization of vesicular GABA transporter with vesicular glutamate transporter-1 and zinc transporter 3, suggesting that GABA can be taken up and stored in synaptic vesicles of MF terminals. Additional fibers releasing both glutamate and GABA into principal cells and interneurons were recruited by increasing the strength of stimulation. Both the GABAergic and the glutamatergic component of synaptic currents occurred with the same latency and were reversibly abolished by l-AP-4, indicating that they originated from the MFs. GABAergic signaling may play a crucial role in tuning hippocampal network during postnatal development. Low-threshold GABA-releasing fibers may undergo elimination, and this may occur when GABA shifts from the depolarizing to the hyperpolarizing direction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.