ArticlePlant physiology2006
The fertilization-induced DNA replication factor MCM6 of maize shuttles between cytoplasm and nucleus, and is essential for plant growth and development.
Article in Plant physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Large-scale single-cell profiling of stem cells identifies redundant regulators of shoot development and yield trait variation.Developmental cell · 2025Article
- Transcriptomic Profiling Highlights Metabolic and Biosynthetic Pathways Involved in In Vitro Flowering inGenes · 2025Article
- High temporal-resolution transcriptome landscapes of maize embryo sac and ovule during early seed development.Plant molecular biology · 2023Article
- Control of pre-replicative complex during the division cycle in Chlamydomonas reinhardtii.PLoS genetics · 2021Article
- The Armadillo BTB Protein ABAP1 Is a Crucial Player in DNA Replication and Transcription of Nematode-Induced Galls.Frontiers in plant science · 2021Article
- Physiological and transcriptomic responses in the seed coat of field-grown soybean (Glycine max L. Merr.) to abiotic stress.BMC plant biology · 2017Article
- Zygotic Genome Activation Occurs Shortly after Fertilization in Maize.The Plant cell · 2017Article
- The plant cell cycle: Pre-Replication complex formation and controls.Genetics and molecular biology · 2017Article
- Differences in Flower Transcriptome between Grapevine Clones Are Related to Their Cluster Compactness, Fruitfulness, and Berry Size.Frontiers in plant science · 2017Article
- Does Early Embryogenesis in Eudicots and Monocots Involve the Same Mechanism and Molecular Players?Plant physiology · 2017Review
- The oak gene expression atlas: insights into Fagaceae genome evolution and the discovery of genes regulated during bud dormancy release.BMC genomics · 2015Article
- The role of the MCM2-7 helicase complex during Arabidopsis seed development.Plant molecular biology · 2014Article
- Germline-specific MATH-BTB substrate adaptor MAB1 regulates spindle length and nuclei identity in maize.The Plant cell · 2012Article
- Regulating DNA replication in plants.Cold Spring Harbor perspectives in biology · 2012Review
- Plant MCM proteins: role in DNA replication and beyond.Plant molecular biology · 2011Review
- A single subunit MCM6 from pea promotes salinity stress tolerance without affecting yield.Plant molecular biology · 2011Article
- A single subunit MCM6 from pea forms homohexamer and functions as DNA helicase.Plant molecular biology · 2010Article
- Dynamic localization of the DNA replication proteins MCM5 and MCM7 in plants.Plant physiology · 2009Article
- Positive regulation of minichromosome maintenance gene expression, DNA replication, and cell transformation by a plant retinoblastoma gene.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- ABAP1 is a novel plant Armadillo BTB protein involved in DNA replication and transcription.The EMBO journal · 2008Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The eukaryotic genome is duplicated exactly once per cell division cycle. A strategy that limits every replication origin to a single initiation event is tightly regulated by a multiprotein complex, which involves at least 20 protein factors. A key player in this regulation is the evolutionary conserved hexameric MCM2-7 complex. From maize (Zea mays) zygotes, we have cloned MCM6 and characterized this essential gene in more detail. Shortly after fertilization, expression of ZmMCM6 is strongly induced. During progression of zygote and proembryo development, ZmMCM6 transcript amounts decrease and are low in vegetative tissues, where expression is restricted to tissues containing proliferating cells. The highest protein amounts are detectable about 6 to 20 d after fertilization in developing kernels. Subcellular localization studies revealed that MCM6 protein shuttles between cytoplasm and nucleoplasm in a cell cycle-dependent manner. ZmMCM6 is taken up by the nucleus during G1 phase and the highest protein levels were observed during late G1/S phase. ZmMCM6 is excluded from the nucleus during late S, G2, and mitosis. Transgenic maize was generated to overexpress and down-regulate ZmMCM6. Plants displaying minor antisense transcript amounts were reduced in size and did not develop cobs to maturity. Down-regulation of ZmMCM6 gene activity seems also to affect pollen development because antisense transgenes could not be propagated via pollen to wild-type plants. In summary, the transgenic data indicate that MCM6 is essential for both vegetative as well as reproductive growth and development in plants.
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