ArticlePlant physiology2006
Rewiring mitogen-activated protein kinase cascade by positive feedback confers potato blight resistance.
Article in Plant physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 92 citations in OpenAlex.
- Potato: from functional genomics to genetic improvement.Molecular horticulture · 2024Review
- Quantitative phosphoproteomics reveals molecular pathway network in wheat resistance to stripe rust.Stress biology · 2024Article
- A novel effector RipBT contributes to Ralstonia solanacearum virulence on potato.Molecular plant pathology · 2023Article
- Functional analysis of mitogen-activated protein kinases (MAPKs) in potato under biotic and abiotic stress.Molecular breeding : new strategies in plant improvement · 2022Review
- Potato StMPK7 is a downstream component of StMKK1 and promotes resistance to the oomycete pathogen Phytophthora infestans.Molecular plant pathology · 2021Article
- A simple method to establish an efficient medium suitable for potato regeneration.Plant biotechnology (Tokyo, Japan) · 2020Article
- RNAi of the sesquiterpene cyclase gene for phytoalexin production impairs pre- and post-invasive resistance to potato blight pathogens.Molecular plant pathology · 2019Article
- Gene Profiling in Late Blight Resistance in Potato Genotype SD20.International journal of molecular sciences · 2018Article
- WRKY Transcription Factors Phosphorylated by MAPK Regulate a Plant Immune NADPH Oxidase in Nicotiana benthamiana.The Plant cell · 2015Article
- AtROP1 negatively regulates potato resistance to Phytophthora infestans via NADPH oxidase-mediated accumulation of H2O2.BMC plant biology · 2014Article
- Toward a systems understanding of plant-microbe interactions.Frontiers in plant science · 2014Review
- MAPK transgenic circuit to improve plant stress-tolerance?Plant signaling & behavior · 2014Review
- The variable domain of a plant calcium-dependent protein kinase (CDPK) confers subcellular localization and substrate recognition for NADPH oxidase.The Journal of biological chemistry · 2013Article
- Soybean MAPK, GMK1 is dually regulated by phosphatidic acid and hydrogen peroxide and translocated to nucleus during salt stress.Molecules and cells · 2012Article
- Article
- Phosphorylation of the Nicotiana benthamiana WRKY8 transcription factor by MAPK functions in the defense response.The Plant cell · 2011Article
- Genomics of fungal disease resistance in tomato.Current genomics · 2010Article
- The Colletotrichum orbiculare SSD1 mutant enhances Nicotiana benthamiana basal resistance by activating a mitogen-activated protein kinase pathway.The Plant cell · 2009Article
- The role of radical burst via MAPK signaling in plant immunity.Plant signaling & behavior · 2008Article
- MAPK signaling regulates nitric oxide and NADPH oxidase-dependent oxidative bursts in Nicotiana benthamiana.The Plant cell · 2008Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Late blight, caused by the notorious pathogen Phytophthora infestans, is a devastating disease of potato (Solanum tuberosum) and tomato (Solanum lycopersicum), and during the 1840s caused the Irish potato famine and over one million fatalities. Currently, grown potato cultivars lack adequate blight tolerance. Earlier cultivars bred for resistance used disease resistance genes that confer immunity only to some strains of the pathogen harboring corresponding avirulence gene. Specific resistance gene-mediated immunity and chemical controls are rapidly overcome in the field when new pathogen races arise through mutation, recombination, or migration from elsewhere. A mitogen-activated protein kinase (MAPK) cascade plays a pivotal role in plant innate immunity. Here we show that the transgenic potato plants that carry a constitutively active form of MAPK kinase driven by a pathogen-inducible promoter of potato showed high resistance to early blight pathogen Alternaria solani as well as P. infestans. The pathogen attack provoked defense-related MAPK activation followed by induction of NADPH oxidase gene expression, which is implicated in reactive oxygen species production, and resulted in hypersensitive response-like phenotype. We propose that enhancing disease resistance through altered regulation of plant defense mechanisms should be more durable and publicly acceptable than engineering overexpression of antimicrobial proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.