ArticleMolecular biology of the cell2006
Cip1 and Cip2 are novel RNA-recognition-motif proteins that counteract Csx1 function during oxidative stress.
Article in Molecular biology of the cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Two Novel Dimorphism-Related Virulence Factors ofInternational journal of molecular sciences · 2021Article
- Article
- Contributions of transcription and mRNA decay to gene expression dynamics of fission yeast in response to oxidative stress.RNA biology · 2014Article
- RrmA regulates the stability of specific transcripts in response to both nitrogen source and oxidative stress.Molecular microbiology · 2013Article
- Cadmium-induced proteome remodeling regulated by Spc1/Sty1 and Zip1 in fission yeast.Toxicological sciences : an official journal of the Society of Toxicology · 2012Article
- Proteomic analysis revealed nitrogen-mediated metabolic, developmental, and hormonal regulation of maize (Zea mays L.) ear growth.Journal of experimental botany · 2012Article
- Widespread cotranslational formation of protein complexes.PLoS genetics · 2011Article
- Fission yeast mitogen-activated protein kinase Sty1 interacts with translation factors.Eukaryotic cell · 2008Article
- Control of mRNA stability by SAPKs.Topics in current genetics · 2008Article
- Multiple pathways differentially regulate global oxidative stress responses in fission yeast.Molecular biology of the cell · 2008Article
- Cytoplasmatic post-transcriptional regulation and intracellular signalling.Molecular genetics and genomics : MGG · 2007Review
- Simplified primer design for PCR-based gene targeting and microarray primer database: two web tools for fission yeast.Yeast (Chichester, England) · 2006Article
- Upf1, an RNA helicase required for nonsense-mediated mRNA decay, modulates the transcriptional response to oxidative stress in fission yeast.Molecular and cellular biology · 2006Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Eukaryotic cells reprogram their global patterns of gene expression in response to stress. Recent studies in Schizosaccharomyces pombe showed that the RNA-binding protein Csx1 plays a central role in controlling gene expression during oxidative stress. It does so by stabilizing atf1(+) mRNA, which encodes a subunit of a bZIP transcription factor required for gene expression during oxidative stress. Here, we describe two related proteins, Cip1 and Cip2, that were identified by multidimensional protein identification technology (MudPIT) as proteins that coprecipitate with Csx1. Cip1 and Cip2 are cytoplasmic proteins that have RNA recognition motifs (RRMs). Neither protein is essential for viability, but a cip1Delta cip2Delta strain grows poorly and has altered cellular morphology. Genetic epistasis studies and whole genome expression profiling show that Cip1 and Cip2 exert posttranscriptional control of gene expression in a manner that is counteracted by Csx1. Notably, the sensitivity of csx1Delta cells to oxidative stress and their inability to induce expression of Atf1-dependent genes are partially rescued by cip1Delta and cip2Delta mutations. This study emphasizes the importance of a modulated mRNA stability in the eukaryotic stress response pathways and adds new information to the role of RNA-binding proteins in the oxidative stress response.
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