ArticleProceedings of the National Academy of Sciences of the United States of America2006
A nucleoporin is required for induction of Ca2+ spiking in legume nodule development and essential for rhizobial and fungal symbiosis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers.
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126 citing papers in PubMed, 376 citations in OpenAlex.
- Responses of arbuscular mycorrhizal wheat to salinity: from symbiotic signaling to stress adaptation.Plant signaling & behavior · 2026Review
- Review
- Putting channels in their place: nucleoporins and symbiotic signaling in legumes.Plant physiology · 2026Article
- Transcriptomic Analysis Reveals the Role ofPlants (Basel, Switzerland) · 2026Article
- Review
- Phosphorylation of rhizobial effector NopZ by soybean NORK promotes association with NENA and enhances nodulation.Nature communications · 2026Article
- Plant cell surface receptors.The Plant journal : for cell and molecular biology · 2026Review
- The role of phase separation for RNA and protein transport through the nuclear pore complex.Journal of experimental botany · 2026Review
- Symbiotic compatibility between Rhizobium laguerreae and its host.Archives of microbiology · 2026Article
- Phosphate deficiency reduces nodule formation through a phosphate starvation response-like protein in Phaseolus vulgaris.Plant & cell physiology · 2025Article
- Nutrient-dependent regulation of symbiotic nitrogen fixation in legumes.Horticulture research · 2025Article
- A mitochondrial metalloprotease FtsH4 is required for symbiotic nitrogen fixation in Lotus japonicus nodules.Scientific reports · 2024Article
- Review
- Article
- Identification and Characterization of Common Bean (Plants (Basel, Switzerland) · 2023Article
- Signaling and Detoxification Strategies in Plant-Microbes Symbiosis under Heavy Metal Stress: A Mechanistic Understanding.Microorganisms · 2022Review
- Nod factor perception: an integrative view of molecular communication during legume symbiosis.Plant molecular biology · 2022Review
- An EfficientInternational journal of molecular sciences · 2022Article
- Innovation and appropriation in mycorrhizal and rhizobial Symbioses.The Plant cell · 2022Article
- Auxin methylation byProceedings of the National Academy of Sciences of the United States of America · 2022Article
66 more citing papers are in PubMed but not listed here.
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16 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Nuclear-cytoplasmic partitioning and traffic between cytoplasmic and nuclear compartments are fundamental processes in eukaryotic cells. Nuclear pore complexes mediate transport of proteins, RNAs and ribonucleoprotein particles in and out of the nucleus. Here we present positional cloning of a plant nucleoporin gene, Nup133, essential for a symbiotic signal transduction pathway shared by Rhizobium bacteria and mycorrhizal fungi. Mutation of Nup133 results in a temperature sensitive nodulation deficient phenotype and absence of mycorrhizal colonization. Root nodules developing with reduced frequency at permissive temperatures are ineffective and electron microscopy show that Rhizobium bacteria are not released from infection threads. Measurement of ion fluxes using a calcium-sensitive dye show that Nup133 is required for the Ca2+ spiking normally detectable within minutes after application of purified rhizobial Nod-factor signal molecules to root hairs. Localization of NUP133 in the nuclear envelope of root cells and root hair cells shown with enhanced yellow fluorescent protein fusion proteins suggests a novel role for NUP133 nucleoporins in a rapid nuclear-cytoplasmic communication after host-plant recognition of symbiotic microbes. Our results identify a component of an intriguing signal process requiring interaction at the cell plasma membrane and at intracellular nuclear and plastid organelle-membranes to induce a second messenger.
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