ArticleProceedings of the National Academy of Sciences of the United States of America2006
Heterogeneous shedding of Escherichia coli O157 in cattle and its implications for control.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers.
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Who cites it
111 citing papers in PubMed.
- Heterogeneous shedding of influenza by human subjects and its implications for epidemiology and control.Scientific reports · 2016Trial
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- Characterization of Ravn virus viral shedding dynamics in experimentally infected Egyptian rousette bats (Journal of virology · 2025Article
- SIRE 2.0: a novel method for estimating polygenic host effects underlying infectious disease transmission, and analytical expressions for prediction accuracies.Genetics, selection, evolution : GSE · 2025Article
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- Sustainable Practices and Microbial Quality of Cattle Offal in Slaughterhouses.Veterinary sciences · 2025Article
- Optimizing contact tracing for avian influenza in poultry flocks.Journal of the Royal Society, Interface · 2025Article
- In Silico Analysis of Shiga Toxin-ProducingToxins · 2024Article
- Quantitative microbial risk assessment forSAGE open medicine · 2024Article
- Comparative Transcriptome Analysis of Shiga Toxin-ProducingMicroorganisms · 2023Article
- Prevalence of Shiga Toxin-ProducingAnimals : an open access journal from MDPI · 2023Article
- Bacteriophages for the Targeted Control of Foodborne Pathogens.Foods (Basel, Switzerland) · 2023Review
- Prevalence and Implications of Shiga Toxin-ProducingPathogens (Basel, Switzerland) · 2022Review
- Super Shedding in Enteric Pathogens: A Review.Microorganisms · 2022Review
- Differential gene expression reveals host factors for viral shedding variation in mallards (The Journal of general virology · 2022Article
- Article
- Prevalence and Whole-Genome Sequence-Based Analysis of Shiga Toxin-Producing Escherichia coli Isolates from the Recto-Anal Junction of Slaughter-Age Irish Sheep.Applied and environmental microbiology · 2021Article
- Strain and host-cell dependent role of type-1 fimbriae in the adherence phenotype of super-shed Escherichia coli O157:H7.International journal of medical microbiology : IJMM · 2021Article
- Evaluation of Cattle for Naturally Colonized Shiga Toxin-ProducingInternational journal of microbiology · 2021Article
51 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors.
Funding
Abstract
Identification of the relative importance of within- and between-host variability in infectiousness and the impact of these heterogeneities on the transmission dynamics of infectious agents can enable efficient targeting of control measures. Cattle, a major reservoir host for the zoonotic pathogen Escherichia coli O157, are known to exhibit a high degree of heterogeneity in bacterial shedding densities. By relating bacterial count to infectiousness and fitting dynamic epidemiological models to prevalence data from a cross-sectional survey of cattle farms in Scotland, we identify a robust pattern: approximately 80% of the transmission arises from the 20% most infectious individuals. We examine potential control options under a range of assumptions about within- and between-host variability in infection dynamics. Our results show that the within-herd basic reproduction ratio, R(0), could be reduced to <1 with targeted measures aimed at preventing infection in the 5% of individuals with the highest overall infectiousness. Alternatively, interventions such as vaccination or the use of probiotics that aim to reduce bacterial carriage could produce dramatic reductions in R(0) by preventing carriage at concentrations corresponding to the top few percent of the observed range of counts. We conclude that a greater understanding of the cause of the heterogeneity in bacterial carriage could lead to highly efficient control measures to reduce the prevalence of E. coli O157.
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