ArticleProceedings of the National Academy of Sciences of the United States of America2006
Human medullary responses to cooling and rewarming the skin: a functional MRI study.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 76 citations in OpenAlex.
- Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets.MedComm · 2026Review
- Distributed Neural Substrates for Autonomic Control During Human Thermoregulation: Brain Network Configurations of Sympathetic and Parasympathetic Innervation.Brain topography · 2026Article
- Revisiting Concepts of Thermal Physiology: Understanding Feedback and Feedforward Control, and Local Temperature Regulation.Acta physiologica (Oxford, England) · 2025Review
- Neural circuits of long-term thermoregulatory adaptations to cold temperatures and metabolic demands.Nature reviews. Neuroscience · 2024Review
- Dopaminergic input from the posterior hypothalamus to the raphe pallidus area inhibits brown adipose tissue thermogenesis.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- In a model of SAH-induced neurogenic fever, BAT thermogenesis is mediated by erythrocytes and blocked by agonism of adenosine A1 receptors.Scientific reports · 2021Article
- Effects of Caffeine on Brown Adipose Tissue Thermogenesis and Metabolic Homeostasis: A Review.Frontiers in neuroscience · 2021Review
- Neural control of fasting-induced torpor in mice.Scientific reports · 2019Article
- Magnetocaloric materials as switchable high contrast ratio MRI labels.Magnetic resonance in medicine · 2019Article
- Apurinic endonuclease-1 preserves neural genome integrity to maintain homeostasis and thermoregulation and prevent brain tumors.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Evaluation of the Combined Effects of Heat and Lighting on the Level of Attention and Reaction Time: Climate Chamber Experiments in Iran.TheScientificWorldJournal · 2018Article
- Shivering thermogenesis in humans: Origin, contribution and metabolic requirement.Temperature (Austin, Tex.) · 2017Review
- In vivo correlates of thermoregulatory defense in humans: Temporal course of sub-cortical and cortical responses assessed with fMRI.Human brain mapping · 2016Article
- Central control of body temperature.F1000Research · 2016Review
- Sympathetic control of reflex cutaneous vasoconstriction in human aging.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Review
- Motion sickness is associated with an increase in vestibular modulation of skin but not muscle sympathetic nerve activity.Experimental brain research · 2015Article
- Temporal sequencing of brain activations during naturally occurring thermoregulatory events.Cerebral cortex (New York, N.Y. : 1991) · 2014Article
- Skin temperature: its role in thermoregulation.Acta physiologica (Oxford, England) · 2014Review
- Functional Imaging of the Human Brainstem during Somatosensory Input and Autonomic Output.Frontiers in human neuroscience · 2013Review
- Low-frequency galvanic vestibular stimulation evokes two peaks of modulation in skin sympathetic nerve activity.Experimental brain research · 2012Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A fall in skin temperature precipitates a repertoire of thermoregulatory responses that reduce the likelihood of a decrease in core temperature. Studies in animals suggest that medullary raphé neurons are essential for cold-defense, mediating both the cutaneous vasoconstrictor and thermogenic responses to ambient cooling; however, the involvement of raphé neurons in human thermoregulation has not been investigated. This study used functional MRI with an anatomically guided region of interest (ROI) approach to characterize changes in the blood oxygen level-dependent (BOLD) signal within the human medulla of nine normal subjects during non-noxious cooling and rewarming of the skin by a water-perfused body suit. An ROI covering 4.9 +/- 0.3 mm(2) in the ventral midline of the medulla immediately caudal to the pons (the rostral medullary raphé) showed an increase in BOLD signal of 3.9% (P < 0.01) during periods of skin cooling, compared with other times. Overall, that signal showed a strong inverse correlation (R = 0.48, P < 0.001) with skin temperature. A larger ROI covering the internal medullary cross section at the same level (area, 126 +/- 15 mm(2)) showed no significant change in mean BOLD signal with cooling (+0.2%, P > 0.05). These findings demonstrate that human rostral medullary raphé neurons are selectively activated in response to a thermoregulatory challenge and point to the location of thermoregulatory neurons homologous to those of the raphé pallidus nucleus in rodents.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.