ArticleProceedings of the National Academy of Sciences of the United States of America2006
Natural variation and genetic covariance in adult hippocampal neurogenesis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.
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Who cites it
100 citing papers in PubMed, 203 citations in OpenAlex.
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- Beyond nature, nurture, and chance: Individual agency shapes divergent learning biographies and brain connectome.Science advances · 2025Article
- Isolation of Adult Hippocampal Neural Stem Cells.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Enhanced Learning and Memory in Patients withGenes · 2024Article
- Altered hippocampal neurogenesis in a mouse model of autism revealed by genetic polymorphisms and by atypical development of newborn neurons.Scientific reports · 2024Article
- Identification of common core ion channel genes in epilepsy and Alzheimer's disease.Irish journal of medical science · 2024Review
- Article
- Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose.PLoS genetics · 2022Article
- CSPα in neurodegenerative diseases.Frontiers in aging neuroscience · 2022Review
- Genome-Wide Association Study on Three Behaviors Tested in an Open Field in Heterogeneous Stock Rats Identifies Multiple Loci Implicated in Psychiatric Disorders.Frontiers in psychiatry · 2022Article
- Lithium treatment and human hippocampal neurogenesis.Translational psychiatry · 2021Article
- Follistatin mediates learning and synaptic plasticity via regulation of Asic4 expression in the hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Characterization of the blood-brain barrier in genetically diverse laboratory mouse strains.Fluids and barriers of the CNS · 2021Article
- Highlights from the Era of Open Source Web-Based Tools.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Predation drives the evolution of brain cell proliferation and brain allometry in male Trinidadian killifish,Proceedings. Biological sciences · 2019Article
- Adult-generated neurons born during chronic social stress are uniquely adapted to respond to subsequent chronic social stress.Molecular psychiatry · 2019Article
- Loss of postnatal quiescence of neural stem cells through mTOR activation upon genetic removal of cysteine string protein-α.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Proteomic Atlas of the Human Brain in Alzheimer's Disease.Journal of proteome research · 2019Article
- Cend1, a Story with Many Tales: From Regulation of Cell Cycle Progression/Exit of Neural Stem Cells to Brain Structure and Function.Stem cells international · 2019Review
40 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Adult hippocampal neurogenesis is highly variable and heritable among laboratory strains of mice. Adult neurogenesis is also remarkably plastic and can be modulated by environment and activity. Here, we provide a systematic quantitative analysis of adult hippocampal neurogenesis in two large genetic reference panels of recombinant inbred strains (BXD and AXB/BXA, n = 52 strains). We combined data on variation in neurogenesis with a new transcriptome database to extract a set of 190 genes with expression patterns that are also highly variable and that covary with rates of (i) cell proliferation, (ii) cell survival, or the numbers of surviving (iii) new neurons, and (iv) astrocytes. Expression of a subset of these neurogenesis-associated transcripts was controlled in cis across the BXD set. These self-modulating genes are particularly interesting candidates to control neurogenesis. Among these were musashi (Msi1h) and prominin1/CD133 (Prom1), both of which are linked to stem-cell maintenance and division. Twelve neurogenesis-associated transcripts had significant cis-acting quantitative trait loci, and, of these, six had plausible biological association with adult neurogenesis (Prom1, Ssbp2, Kcnq2, Ndufs2, Camk4, and Kcnj9). Only one cis-acting candidate was linked to both neurogenesis and gliogenesis, Rapgef6, a downstream target of ras signaling. The use of genetic reference panels coupled with phenotyping and global transcriptome profiling thus allowed insight into the complexity of the genetic control of adult neurogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.