ArticleProceedings of the National Academy of Sciences of the United States of America2006
Two types of cytotoxic lymphocyte regulation explain kinetics of immune response to human immunodeficiency virus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- An Evolutionary Model of Progression to AIDS.Microorganisms · 2020Article
- Modeling the immune response to HIV infection.Current opinion in systems biology · 2018Article
- The route of HIV escape from immune response targeting multiple sites is determined by the cost-benefit tradeoff of escape mutations.PLoS computational biology · 2014Article
- The Effect of Interference on the CD8(+) T Cell Escape Rates in HIV.Frontiers in immunology · 2014Article
- Design requirements for interfering particles to maintain coadaptive stability with HIV-1.Journal of virology · 2013Article
- Kinetics of the viral cycle influence pharmacodynamics of antiretroviral therapy.Biology direct · 2011Article
- Estimate of effective recombination rate and average selection coefficient for HIV in chronic infection.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Interpreting the effect of vaccination on steady state infection in animals challenged with Simian immunodeficiency virus.Journal of theoretical biology · 2010Article
- Model with two types of CTL regulation and experiments on CTL dynamics.Journal of theoretical biology · 2010Article
- Constraints on the dominant mechanism for HIV viral dynamics in patients on raltegravir.Antiviral therapy · 2009Article
- Decay dynamics of HIV-1 depend on the inhibited stages of the viral life cycle.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Low-level HIV-1 replication and the dynamics of the resting CD4+ T cell reservoir for HIV-1 in the setting of HAART.BMC infectious diseases · 2008Article
- Understanding the failure of CD8+ T-cell vaccination against simian/human immunodeficiency virus.Journal of virology · 2007Article
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Authors and funding
3 authors.
Funding
Abstract
The organization of the cytotoxic T lymphocyte (CTL) response at organismal level is poorly understood. We propose a mathematical model describing the interaction between HIV and its host that explains 20 quantitative observations made in HIV-infected individuals and simian immunodeficiency virus-infected monkeys, including acute infection and response to various antiretroviral therapy regimens. The model is built on two modes of CTL activation: direct activation by infected cells and indirect activation by CD4 helper cells activated by small amounts of virus. Effective infection of helper cells by virus leads to a stable chronic infection at high virus load. We assume that CTLs control virus by killing infected cells. We explain the lack of correlation between the CTL number and the virus decay rate in therapy and predict that individuals with a high virus load can be switched to a low-viremia state that will maintain stability after therapy, but the switch requires fine adjustment of therapy regimen based on the model and individual parameters.
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