ArticleChromosoma2006
Gene-rich and gene-poor chromosomal regions have different locations in the interphase nuclei of cold-blooded vertebrates.
Article in Chromosoma, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 54 citations in OpenAlex.
- Evolution of chromosomes and nuclear architectures of amniotes.Nature communications · 2025Article
- Origin and Evolution of Genes in Eukaryotes: Mechanisms, Dynamics, and Functional Implications.Genes · 2025Review
- De novo genome assemblies of two cryptodiran turtles with ZZ/ZW and XX/XY sex chromosomes provide insights into patterns of genome reshuffling and uncover novel 3D genome folding in amniotes.Genome research · 2024Article
- The Chromatin Organization Close to SNP rs12913832, Involved in Eye Color Variation, Is Evolutionary Conserved in Vertebrates.International journal of molecular sciences · 2024Article
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- Epigenetic regulatory layers in the 3D nucleus.Molecular cell · 2024Review
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- Chromosomal Rearrangements and Altered Nuclear Organization: Recent Mechanistic Models in Cancer.Cancers · 2021Review
- The "Genomic Code": DNA Pervasively Moulds Chromatin Structures Leaving no Room for "Junk".Life (Basel, Switzerland) · 2021Review
- A new emu genome illuminates the evolution of genome configuration and nuclear architecture of avian chromosomes.Genome research · 2021Article
- Three-dimensional chromatin in infectious disease-A role for gene regulation and pathogenicity?PLoS pathogens · 2021Review
- GPSeq reveals the radial organization of chromatin in the cell nucleus.Nature biotechnology · 2020Article
- 3-D Nucleus Architecture in Oat × Maize Addition Lines.International journal of molecular sciences · 2020Article
- Radial Organization in the Mammalian Nucleus.Frontiers in genetics · 2020Review
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- Spatial organization of chromosome territories in the interphase nucleus of trisomy 21 cells.Chromosoma · 2018Article
- Review
- DHSpred: support-vector-machine-based human DNase I hypersensitive sites prediction using the optimal features selected by random forest.Oncotarget · 2018Article
- The Role of Chromatin Structure in Gene Regulation of the Human Malaria Parasite.Trends in parasitology · 2017Review
- The arrangement of Brachypodium distachyon chromosomes in interphase nuclei.Journal of experimental botany · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In situ hybridizations of single-copy GC-rich, gene-rich and GC-poor, gene-poor chicken DNA allowed us to localize the gene-rich and the gene-poor chromosomal regions in interphase nuclei of cold-blooded vertebrates. Our results showed that the gene-rich regions from amphibians (Rana esculenta) and reptiles (Podarcis sicula) occupy the more internal part of the nuclei, whereas the gene-poor regions occupy the periphery. This finding is similar to that previously reported in warm-blooded vertebrates, in spite of the lower GC levels of the gene-rich regions of cold-blooded vertebrates. This suggests that this similarity extends to chromatin structure, which is more open in the gene-rich regions of both mammals and birds and more compact in the gene-poor regions. In turn, this may explain why the compositional transition undergone by the genome at the emergence of homeothermy did not involve the entire ancestral genome but only a small part of it, and why it involved both coding and noncoding sequences. Indeed, the GC level increased only in that part of the genome that needed a thermodynamic stabilization, namely in the more open gene-rich chromatin of the nuclear interior, whereas the gene-poor chromatin of the periphery was stabilized by its own compact structure.
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