ArticleHistochemistry and cell biology2006
Immunohistochemical and in situ hybridization analysis of galectin-3, a beta-galactoside binding lectin, in the urinary system of adult mice.
Article in Histochemistry and cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 32 citations in OpenAlex.
- The interferon-β/STAT1 axis drives the collective invasion of skin squamous cell carcinoma with sealed intercellular spaces.Oncogenesis · 2022Article
- Galectin-3 in Kidney Diseases: From an Old Protein to a New Therapeutic Target.International journal of molecular sciences · 2022Review
- A novel immunofluorescence detection method for renal cell-type specific in situ cytokine production by confocal microscopy.MethodsX · 2020Article
- Uromodulin regulates renal magnesium homeostasis through the ion channel transient receptor potential melastatin 6 (TRPM6).The Journal of biological chemistry · 2018Article
- Proximal Tubule CD73 Is Critical in Renal Ischemia-Reperfusion Injury Protection.Journal of the American Society of Nephrology : JASN · 2017Article
- Immunolocalization of galectin-3 in mouse testicular tissue.Iranian journal of basic medical sciences · 2011Article
- Differential cellular localization of galectin-1 and galectin-3 in the regressing corpus luteum of mice and their possible contribution to luteal cell elimination.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2010Article
- Immunohistochemical localization of six galectin subtypes in the mouse digestive tract.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2009Article
- Galectin-3 associates with the primary cilium and modulates cyst growth in congenital polycystic kidney disease.The American journal of pathology · 2006Article
- Galectin-3 as a Potential Biomarker of Microvascular Complications in Patients with Type 2 Diabetes.Indian journal of endocrinology and metabolismArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Galectin is an animal lectin that has high affinity to beta-galactoside of glycoconjugates. In the present study, cellular expression of galectin subtypes in the urinary system of adult mice was examined by in situ hybridization and immunohistochemistry. The major subtype expressed in the murine urinary system was galectin-3, which was expressed continuously from the kidney to the distal end of the urethra. The renal cortex expressed galectin-3 more intensely than the medulla. Renal galectin-3 immunoreactivity was strongest in the cortical collecting ducts, where principal cells were the sole cellular source. All cell layers of the transitional epithelium from the renal pelvis to the urethra strongly expressed galectin-3 at the mRNA and protein levels. An electron microscopic study demonstrated diffuse cytoplasmic localization of galectin-3 in principal cells of the collecting ducts and in the bladder epithelial cells. Urethral galectin-3 expression at the pars spongiosa decreased in intensity near the external urethral orifice, where the predominant subtype of galectin was substituted by galectin-7. The muscular layer of the ureter and urinary bladder contained significant signals for galectin-1. Taken together, the observations indicate that the adult urinary system shows intense and selective expression of galectin-3 in epithelia of the uretic bud- and cloaca-derivatives.
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