Evidence map›Paper›PMID 16404492›Full record

Trial reportOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2006

Intensity of exercise is associated with bone density change in premenopausal women.

A Vainionpää, R Korpelainen, E Vihriälä, A Rinta-Paavola, J Leppäluoto, T Jämsä

Registry-linked trialAbstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02984553 (The Use of Lactate Thresholds to Individualize Accelerometer Cut-points and Objectively Assess Physical Activity Levels in Postmenopausal Women), which is not on this map. Cited by 69 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 6 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02984553 unknown statusnot on this mapstarted 2015, after this paper: background citation

The Use of Lactate Thresholds to Individualize Accelerometer Cut-points and Objectively Assess Physical Activity Levels in Postmenopausal Women

TypeobservationalSponsorCentro de Estudios, Investigación y Medicina del DeporteRan2015 to 2017Enrolled80ConditionsPrimary Prevention
3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 6 syntheses or guidelines pooled it, 179 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
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  6. Pooled it
  7. Effect of 6-month high-impact step aerobics and resistance training on BMD and tibial bending strength in sedentary premenopausal women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Trial
  8. Physical Activity Across Adulthood and Bone Health in Later Life: The 1946 British Birth Cohort.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019
    Trial
  9. Effects of ZumbaMedicina (Kaunas, Lithuania) · 2019
    Trial
  10. Effects of a 20-week high-intensity strength and sprint training program on tibial bone structure and strength in middle-aged and older male sprint athletes: a randomized controlled trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Trial
  11. Trial
  12. Effect of progressive high-impact exercise on femoral neck structural strength in postmenopausal women with mild knee osteoarthritis: a 12-month RCT.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Trial
  13. Trial
  14. Effect of supervised and home exercise training on bone mineral density among breast cancer patients. A 12-month randomised controlled trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012
    Trial
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  18. Effect of impact exercise on bone metabolism.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2009
    Trial
  19. Effects of a multi-component exercise program and calcium-vitamin-D3-fortified milk on bone mineral density in older men: a randomised controlled trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2009
    Trial
  20. Weight-bearing bones are more sensitive to physical exercise in boys than in girls during pre- and early puberty: a cross-sectional study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2008
    Trial

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

A VainionpääDepartment of Medical Technology, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland. avainion@mail.student.oulu.fi
R Korpelainen
E Vihriälä
A Rinta-Paavola
J Leppäluoto
T Jämsä
University of Oulu · FIOulu University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHigh-impact exercise is known to be beneficial for bones. However, the optimal amount of exercise is not known. The aim of the present study was to evaluate the association between the intensity of exercise and bone mineral density (BMD).

methodsWe performed a 12-month population-based trial with 120 women (aged 35-40 years) randomly assigned to an exercise group or to a control group. The intensity of the physical activity of 64 women was assessed with an accelerometer-based body movement monitor. The daily activity was analyzed at five acceleration levels (0.3-1.0 g, 1.1-2.4 g, 2.5-3.8 g, 3.9-5.3 g, and 5.4-9.2 g). BMD was measured at the hip, spine (L1-L4), and radius by dual-energy x-ray absorptiometry. The calcaneus was measured using quantitative ultrasound.

resultsPhysical activity that induced acceleration levels exceeding 3.9 g correlated positively with the BMD change in the hip area (p<0.05-0.001). L1 BMD change correlated positively with activity exceeding 5.4 g (p<0.05) and calcaneal speed of sound with the level of 1.1-2.4 g (p< 0.05). Baseline BMD was negatively associated with the BMD change at the hip.

conclusionThe intensity of exercise, measured as the acceleration level of physical activity, was significantly correlated with BMD changes. Bone stimulation is reached during normal physical exercise in healthy premenopausal women. In the hip area, the threshold level for improving BMD is less than 100 accelerations per day at levels exceeding 3.9 g.

Indexed as

AdultAnthropometryBone DensityCase-Control StudiesExerciseFemaleFinlandHumansPhysical Education and TrainingPremenopauseRegression Analysis

Identifiers

PMID16404492
OpenAlexW1993894079

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.