ArticleEuropean journal of clinical nutrition2006
Low maternal vitamin B12 status is associated with intrauterine growth retardation in urban South Indians.
Article in European journal of clinical nutrition, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00641862 (Randomized Trial of Vitamin B12 in Pregnant Indian Women), which is not on this map. Cited by 68 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Trial of Vitamin B12 in Pregnant Indian Women
Who cites it
68 citing papers in PubMed, 4 syntheses or guidelines pooled it, 179 citations in OpenAlex.
- Vitamin B12 supplementation during pregnancy for maternal and child health outcomes.The Cochrane database of systematic reviews · 2024Pooled it
- Maternal Vitamin B12 Status During Pregnancy and Its Association With Outcomes of Pregnancy and Health of the Offspring: A Systematic Review and Implications for Policy in India.Frontiers in endocrinology · 2021Pooled it
- Associations of Maternal Vitamin B12 Concentration in Pregnancy With the Risks of Preterm Birth and Low Birth Weight: A Systematic Review and Meta-Analysis of Individual Participant Data.American journal of epidemiology · 2017Pooled it
- Association between vitamin B12 intake and EURRECA's prioritized biomarkers of vitamin B12 in young populations: a systematic review.Public health nutrition · 2013Pooled it
- Cobalamin and folate status in women during early pregnancy in Bhaktapur, Nepal.Journal of nutritional science · 2021Trial
- Trial
- A Daily Snack Containing Leafy Green Vegetables, Fruit, and Milk before and during Pregnancy Prevents Gestational Diabetes in a Randomized, Controlled Trial in Mumbai, India.The Journal of nutrition · 2016Trial
- Vitamin B-12 supplementation during pregnancy and early lactation increases maternal, breast milk, and infant measures of vitamin B-12 status.The Journal of nutrition · 2014Trial
- Article
- Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025Review
- Dietary pattern and nutritional assessment in a cohort of mothers identified by neonatal screening for cobalamin deficiency in offspring: an Italian single center experience.Frontiers in nutrition · 2025Article
- Review
- Review
- Cord Blood Proteomic Profiles, Birth Weight, and Early Life Growth Trajectories.JAMA network open · 2024Article
- Folate and vitamin BBirth defects research · 2024Article
- Single-blinded, stratified, dose ranging trial to assess pharmacokinetics and identify optimal dose of vitamin B12 in pregnancy in Tanzania.Gates open research · 2024Article
- Bioactive Ingredients from Dairy-Based Lactic Acid Bacterial Fermentations for Functional Food Production and Their Health Effects.Nutrients · 2023Review
- Article
- Vitamins and minerals, education, and self-care need during preconception to 1000 days of life in Southeast Asia: An expert panel opinion.SAGE open medicine · 2023Review
- NADThe Journal of reproduction and development · 2022Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the maternal sociodemographic, anthropometric, dietary and micronutrient status in apparently healthy pregnant women in order to determine their associations with intrauterine growth retardation (IUGR).
designProspective observational study.
settingBangalore City, India. SUBJECTS: A total of 478 women were recruited at 12.9+/-3.3 weeks of gestation and followed up at the first, second and third trimesters of pregnancy and at delivery. The dropout rate was 8.5%.
interventionsNone.
main outcome measuresBirth weight was measured at hospital delivery.
resultsThe mean birth weight was 2.85+/-0.45 kg. In all, 28.6% of newborns were IUGR. There was a strong inverse relationship between maternal educational level and risk of IUGR. A low body weight at baseline was also associated with a high risk of IUGR. Compared with women in the highest quartile for second trimester weight gain, those in the lowest quartile had a significantly higher adjusted odds ratio (AOR: 3.98; 95% CI: 1.83, 8.65) for IUGR. Women in the lowest tertile for serum vitamin B(12) concentration during each of the three trimesters of pregnancy had significantly higher risk of IUGR (AOR: 5.98, 9.28 and 2.81 for trimesters 1-3, respectively).
conclusionsThe present study demonstrates associations between educational status, maternal weight and gestational weight gain with IUGR. Importantly, in a subsample, there were strong associations of vitamin B(12) status with IUGR, suggesting that better socioeconomic conditions, improved nutritional status and early detection of vitamin B(12) deficiency in pregnancy combined with appropriate interventions are likely to play an important role in reducing IUGR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.