ArticleChromosoma2006
From the trap to the basket: getting to the bottom of the nuclear pore complex.
Article in Chromosoma, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Invasion and Propagation of White Spot Syndrome Virus: Hijacking of the Cytoskeleton, Intracellular Transport Machinery, and Nuclear Import Transporters.Journal of virology · 2022Article
- Modeling of the mechano-chemical behaviour of the nuclear pore complex: current research and perspectives.Integrative biology : quantitative biosciences from nano to macro · 2016Review
- Structural characterization of altered nucleoporin Nup153 expression in human cells by thin-section electron microscopy.Nucleus (Austin, Tex.) · 2014Article
- Depletion of nucleoporins from HeLa nuclear pore complexes to facilitate the production of ghost pores for in vitro reconstitution.Cytotechnology · 2013Article
- Nucleocytoplasmic transport: a role for nonspecific competition in karyopherin-nucleoporin interactions.Molecular & cellular proteomics : MCP · 2012Article
- The yeast nuclear pore complex and transport through it.Genetics · 2012Article
- Single-molecule transport across an individual biomimetic nuclear pore complex.Nature nanotechnology · 2011Article
- Biophysical coarse-grained modeling provides insights into transport through the nuclear pore complex.Biophysical journal · 2011Article
- Comparative genomic evidence for a complete nuclear pore complex in the last eukaryotic common ancestor.PloS one · 2010Article
- Mifepristone increases gamma-retroviral infection efficiency by enhancing the integration of virus into the genome of infected cells.Gene therapy · 2010Article
- Nucleoporin 153 arrests the nuclear import of hepatitis B virus capsids in the nuclear basket.PLoS pathogens · 2010Article
- Organization and regulation of nucleocytoplasmic transport.Molecular biology · 2010Review
- Evidence for a shared nuclear pore complex architecture that is conserved from the last common eukaryotic ancestor.Molecular & cellular proteomics : MCP · 2009Article
- On the octagonal structure of the nuclear pore complex: insights from coarse-grained models.Biophysical journal · 2008Article
- Towards reconciling structure and function in the nuclear pore complex.Histochemistry and cell biology · 2008Review
- Biology and biophysics of the nuclear pore complex and its components.International review of cell and molecular biology · 2008Review
- Nuclear mRNA export requires specific FG nucleoporins for translocation through the nuclear pore complex.The Journal of cell biology · 2007Article
- Multiple conserved domains of the nucleoporin Nup124p and its orthologs Nup1p and Nup153 are critical for nuclear import and activity of the fission yeast Tf1 retrotransposon.Molecular biology of the cell · 2007Article
- Intracellular transport of hepatitis B virus.World journal of gastroenterology · 2007Review
- Managing free-energy barriers in nuclear pore transport.Journal of biological physics · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear pore complexes (NPCs) are large supramolecular assemblies that perforate the double-membraned nuclear envelope and serve as the sole gateways of molecular exchange between the cytoplasm and the nucleus in interphase cells. Combining novel specimen preparation regimes with innovative use of high-resolution scanning electron microscopy, Hans Ris produced in the late eighties stereo images of the NPC with unparalleled clarity and structural detail, thereby setting new standards in the field. Since that time, efforts undertaken to resolve the molecular structure and architecture, and the numerous interactions that occur between NPC proteins (nucleoporins), soluble transport receptors, and the small GTPase Ran, have led to a deeper understanding of the functional role of NPCs in nucleocytoplasmic transport. In spite of these breakthroughs, getting to the bottom of the actual cargo translocation mechanism through the NPC remains elusive and controversial. Here, we review recent insights into NPC function by correlating structural findings with biochemical data. By introducing new experimental and computational results, we reexamine how NPCs can discriminate between receptor-mediated and passive cargo to promote vectorial translocation in a highly regulated manner. Moreover, we comment on the importance and potential benefits of identifying and experimenting with individual key components implicated in the translocation mechanism. We conclude by dwelling on questions that we feel are pertinent to a more rational understanding of the physical aspects governing NPC mechanics. Last but not least, we substantiate these uncertainties by boldly suggesting a new direction in NPC research as a means to verify such novel concepts, for example, a de novo designed 'minimalist' NPC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.