ArticlePflugers Archiv : European journal of physiology2006
Relationship between oxidative stress in muscle tissue and weight-lifting-induced muscle damage.
Article in Pflugers Archiv : European journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 53 citations in OpenAlex.
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- Effects of allicin supplementation on plasma markers of exercise-induced muscle damage, IL-6 and antioxidant capacity.European journal of applied physiology · 2008Trial
- Comparison of Hormonal, Inflammatory, Muscle Damage and Oxidative Stress Biomarkers Changes in Response to High-Intensity Interval, Circuit and Concurrent Exercise Bouts.Sports (Basel, Switzerland) · 2025Article
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- Short-Term Oral Quercetin Supplementation Improves Post-exercise Insulin Sensitivity, Antioxidant Capacity and Enhances Subsequent Cycling Time to Exhaustion in Healthy Adults: A Pilot Study.Frontiers in nutrition · 2022Article
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- A review on the mechanisms of blood-flow restriction resistance training-induced muscle hypertrophy.Sports medicine (Auckland, N.Z.) · 2015Review
- On fuel choice and water balance during migratory bird flights.International biology review · 2015Article
- Biomarkers of peripheral muscle fatigue during exercise.BMC musculoskeletal disorders · 2012Review
- Effects of light emitting diode (LED) therapy and cold water immersion therapy on exercise-induced muscle damage in rats.Lasers in medical science · 2012Article
- Whey protein precludes lipid and protein oxidation and improves body weight gain in resistance-exercised rats.European journal of nutrition · 2011Article
- Cell-free plasma DNA and purine nucleotide degradation markers following weightlifting exercise.European journal of applied physiology · 2010Article
- Effects of glutathione depletion and age on skeletal muscle performance and morphology following chronic stretch-shortening contraction exposure.European journal of applied physiology · 2010Article
- Acute exercise and oxidative stress: a 30 year history.Dynamic medicine : DM · 2009Article
- Resistance exercise effects on blood glutathione status and plasma protein carbonyls: influence of partial vascular occlusion.European journal of applied physiology · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined whether oxidative stress-induced muscle damage occurs during weight-lifting exercise using the rat model. Male Wistar rats were subjected to a single exhaustive session of weight-lifting exercise, and dynamics of blood volume and hemoglobin levels in the exercising muscle were monitored by near-infrared spectroscopy. Total muscle damage was evaluated by the efflux of serum creatine kinase (CK) and uptake of [(3)H]thymidine. The production of reactive oxygen species (ROS) in the muscle was estimated by serial changes in total superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT) activities (established indirect markers). Immunohistochemical detection of GPX was also performed. A relatively anoxic state occurred repeatedly after every exercise set in exercising muscle following rapid blood reperfusion and was similar to an ischemia-reperfusion state. Serum CK and mitotic activity in the muscle consistently increased, and damaged muscle fibers that reacted positively to anti-GPX antibody were also observed after exercise. Serial changes in total SOD, GPX, and CAT activities were biphasic and exhibited peaks immediately and 24-72 h after exercise. The first increase was caused by a repeated ischemia-reperfusion-like state following weight-lifting exercise, and the second was dependent on the accumulation of infiltrated phagocytic cells at the damaged portions. These results suggest that ROS-induced muscle fiber damage occurred as a consequence of weight-lifting exercise.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.