ArticlePsychopharmacology2006
Neuroactive steroids, negative affect, and nicotine dependence severity in male smokers.
Article in Psychopharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00538070 (The Effects of Glycine Transport Inhibition on Brain Glycine Concentration), which is not on this map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Glycine Transport Inhibition on Brain Glycine Concentration
Who cites it
28 citing papers in PubMed, 50 citations in OpenAlex.
- Effects of progesterone stimulated allopregnanolone on craving and stress response in cocaine dependent men and women.Psychoneuroendocrinology · 2016Trial
- DHEA metabolism to the neurosteroid androsterone: a possible mechanism of DHEA's antidepressant action.Psychopharmacology · 2015Trial
- A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Trial
- Proof-of-concept randomized controlled trial of pregnenolone in schizophrenia.Psychopharmacology · 2014Trial
- The neurosteroids allopregnanolone and dehydroepiandrosterone modulate resting-state amygdala connectivity.Human brain mapping · 2014Trial
- DHEA enhances emotion regulation neurocircuits and modulates memory for emotional stimuli.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Trial
- Allopregnanolone elevations following pregnenolone administration are associated with enhanced activation of emotion regulation neurocircuits.Biological psychiatry · 2013Trial
- Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2009Trial
- Salivary stress biomarkers of recent nicotine use and dependence.The American journal of drug and alcohol abuse · 2016Article
- Brain and Serum Androsterone Is Elevated in Response to Stress in Rats with Mild Traumatic Brain Injury.Frontiers in neuroscience · 2016Article
- Potential neurobiological benefits of exercise in chronic pain and posttraumatic stress disorder: Pilot study.Journal of rehabilitation research and development · 2016Article
- Allopregnanolone association with psychophysiological and cognitive functions during acute smoking abstinence in premenopausal women.Experimental and clinical psychopharmacology · 2015Article
- Association of DHEA, DHEAS, and cortisol with childhood trauma exposure and post-traumatic stress disorder.International clinical psychopharmacology · 2014Article
- Menstrual phase, depressive symptoms, and allopregnanolone during short-term smoking cessation.Experimental and clinical psychopharmacology · 2013Article
- Potential substrates for nicotine and alcohol interactions: a focus on the mesocorticolimbic dopamine system.Biochemical pharmacology · 2013Review
- Smoking behaviour and mental health disorders--mutual influences and implications for therapy.International journal of environmental research and public health · 2013Review
- The association of dehydroepiandrosterone and dehydroepiandrosterone sulfate with anxiety sensitivity and electronic diary negative affect among smokers with and without posttraumatic stress disorder.Journal of clinical psychopharmacology · 2013Article
- Development of novel pharmacotherapeutics for tobacco dependence: progress and future directions.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2012Review
- Neuroimaging insights into the role of cortical GABA systems and the influence of nicotine on the recovery from alcohol dependence.Neuropharmacology · 2011Review
- Neurosteroids and self-reported pain in veterans who served in the U.S. Military after September 11, 2001.Pain medicine (Malden, Mass.) · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
rationaleNicotine administration alters neuroactive steroids in rodent models, and serum levels of the neuroactive steroid DHEAS (dehydroepiandrosterone sulfate) appear to be higher in smokers. These molecules may be relevant to tobacco addiction and affective symptoms.
objectivesThis study aims to investigate DHEAS, allopregnanolone, pregnenolone, and other steroids in male smokers to determine potential associations with nicotine dependence severity and negative affect. MATERIALS AND
methodsAllopregnanolone and pregnenolone serum levels were determined by gas chromatography/mass spectrometry, while DHEAS and other steroid levels were determined by radioimmunoassay in 28 male smokers. Correlational analyses were performed to determine potential associations with rating measures, including the Fagerstrom Test for Nicotine Dependence (FTND), the addiction subscale of the Ikard Smoking Motivation Questionnaire (ISMQ), the craving item on the Reasons to Smoke (RTS) Questionnaire, and the negative affect and craving subscales of the Shiffman-Jarvik Withdrawal Questionnaire.
resultsDHEAS levels were inversely correlated with the negative affect subscale of the Shiffman-Jarvik Withdrawal Questionnaire (r=-0.60, p=0.002) and the RTS craving item (r=-0.43, p=0.03), and tended to be inversely correlated with the FTND scores (r=-0.38, p=0.067) and the ISMQ addiction subscale (r=-0.38, p=0.059), adjusting for age. Allopregnanolone levels were positively correlated with cotinine levels (r=0.57, p=0.006); pregnenolone levels tended to be positively correlated with cotinine levels (r=0.40, p=0.066).
conclusionsDHEAS levels were inversely correlated with negative affect and craving measures, and may predict nicotine dependence severity. Allopregnanolone levels were positively correlated with cotinine levels, suggesting that this neuroactive steroid may be upregulated in smokers. Neuroactive steroids may represent novel smoking cessation agents.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.