SynthesisMolecular psychiatry2006
Further evidence for the association between G72/G30 genes and schizophrenia in two ethnically distinct populations.
Synthesis in Molecular psychiatry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Further evidence for an association of G72/G30 with schizophrenia in Chinese.Schizophrenia research · 2009Pooled it
- Allelic association of G72/G30 with schizophrenia and bipolar disorder: a comprehensive meta-analysis.Schizophrenia research · 2008Pooled it
- Locus-Specific Genetic Associations at theAdvanced genetics (Hoboken, N.J.) · 2026Article
- The Genetic Markers of Knee Osteoarthritis in Women from Russia.Biomedicines · 2024Article
- d-Amino Acids and pLG72 in Alzheimer's Disease and Schizophrenia.International journal of molecular sciences · 2021Review
- Association Analysis Between the rs1899663 Polymorphism of HOTAIR and Risk of Psychiatric Conditions in an Iranian Population.Journal of molecular neuroscience : MN · 2020Article
- pLG72 levels increase in early phase of Alzheimer's disease but decrease in late phase.Scientific reports · 2019Article
- Combination ofFrontiers in psychiatry · 2018Article
- MicroRNA-137 Inhibits EFNB2 Expression Affected by a Genetic Variant and Is Expressed Aberrantly in Peripheral Blood of Schizophrenia Patients.EBioMedicine · 2016Article
- Long noncoding RNAs in psychiatric disorders.Psychiatric genetics · 2016Review
- Association between genetic variants of DVWA and osteoarthritis of the knee and hip: a comprehensive meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Identification of pLG72-Induced Oxidative Stress Using Systemic Approaches.BioMed research international · 2015Article
- The C-terminal region of G72 increases D-amino acid oxidase activity.International journal of molecular sciences · 2013Article
- Association of PDE4B polymorphisms and schizophrenia in Northwestern Han Chinese.Human genetics · 2012Article
- Genetic evidence for the association between the early growth response 3 (EGR3) gene and schizophrenia.PloS one · 2012Article
- Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia.The American journal of psychiatry · 2011Article
- Relationships between COL2A1 gene polymorphisms and knee osteoarthritis in Han Chinese women.Molecular biology reports · 2011Article
- Population-based and family-based association studies of ZNF804A locus and schizophrenia.Molecular psychiatry · 2011Article
- Meta-analysis of haplotype-association studies: comparison of methods and empirical evaluation of the literature.BMC genetics · 2011Article
- G72 influences longitudinal change in frontal lobe volume in schizophrenia.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, the nested genes G72 and G30 on chromosome 13q32-q33 have been implicated in the etiology of schizophrenia. We genotyped six single-nucleotide polymorphisms (SNPs: rs3916965, rs3916967, rs2391191, rs778294, rs779293 and rs3918342), which span approximately 82.5 kb in the region encompassing the G72/G30 genes in 1176 Han Chinese subjects (588 cases and 588 controls) and 365 Scottish subjects (183 cases and 182 controls). Significant association between an allele of marker rs778293 and schizophrenia was found in our Chinese samples (P = 0.0013), and was replicated in the Scottish samples (P = 0.022). LD analysis revealed that four SNPs between rs3916965 and rs778294 were in LD, called block I, and the two distal SNPs (rs778293 and rs3918342) constituted a block II in both the Chinese and Scottish samples. We selected one SNP from each block (rs778294 from block I and rs778293 from block II), and then analyzed the haplotypes. A significant difference was observed for the common haplotype GC in the Chinese sample (P = 0.0145), and was replicated in the Scottish sample (P = 0.003). On meta-analysis, we separately analyzed the studies in Asian and European populations because of significant heterogeneity in the homogeneity test. We found a statistically significant association between rs778293 and schizophrenia in Asian populations, but no difference was found between cases and controls in the European populations. Overall, our data give further support to the existing evidence that G72/G30 genes are involved in conferring susceptibility to schizophrenia.
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