Evidence map›Paper›PMID 16402119›Full record

ReviewBritish journal of pharmacology2006

Pharmacology of intracellular signalling pathways.

Stefan R Nahorski

Open access · bronzeAbstract readHistorical ArticlePortraitReview
In one paragraph

Review in British journal of pharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Stefan R NahorskiDepartment of Cell Physiology and Pharmacology, University of Leicester, Medical Sciences Building, University Road, Leicester LE1 9HN. srn@le.ac.uk
University of Leicester · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

This article provides a brief and somewhat personalized review of the dramatic developments that have occurred over the last 45 years in our understanding of intracellular signalling pathways associated with G-protein-coupled receptor activation. Signalling via cyclic AMP, the phosphoinositides and Ca(2+) is emphasized and these systems have already been revealed as new pharmacological targets. The therapeutic benefits of most of such targets are, however, yet to be realized, but it is certain that the discipline of pharmacology needs to widen its boundaries to meet these challenges in the future.

Indexed as

Signal TransductionAnimalsCalcium SignalingCyclic AMPHistory, 20th CenturyHistory, 21st CenturyHumansInositol 1,4,5-Trisphosphate ReceptorsLithium CompoundsPhosphatidylinositolsReceptors, G-Protein-CoupledSecond Messenger SystemsCyclic AMPInositol 1,4,5-Trisphosphate ReceptorsLithium CompoundsPhosphatidylinositolsReceptors, G-Protein-Coupled

Identifiers

PMID16402119
PMCPMC1760751
OpenAlexW1742311610

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.