ReviewBritish journal of pharmacology2006
Agonist-activated ion channels.
Review in British journal of pharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Derepression may masquerade as activation in ligand-gated ion channels.Nature communications · 2023Article
- Origin of acetylcholine antagonism in ELIC, a bacterial pentameric ligand-gated ion channel.Communications biology · 2022Article
- Paradoxical Potentiation of Acid-Sensing Ion Channel 3 (ASIC3) by AmilorideFrontiers in physiology · 2021Article
- Kinetic control of stationary flux ratios for a wide range of biochemical processes.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Measurement of smooth muscle function in the isolated tissue bath-applications to pharmacology research.Journal of visualized experiments : JoVE · 2015Article
- GABAergic transmission to kisspeptin neurons is differentially regulated by time of day and estradiol in female mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Mutational analysis of cysteine residues of the insect odorant co-receptor (Orco) from Drosophila melanogaster reveals differential effects on agonist- and odorant-tuning receptor-dependent activation.The Journal of biological chemistry · 2014Article
- Agonists binding nicotinic receptors elicit specific channel-opening patterns at αγ and αδ sites.The Journal of physiology · 2014Article
- Simplification of reversible Markov chains by removal of states with low equilibrium occupancy.Journal of theoretical biology · 2012Article
- Article
- Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors.Nature communications · 2011Article
- Ion-dependent gating of kainate receptors.The Journal of physiology · 2010Review
- Structural basis of activation of cys-loop receptors: the extracellular-transmembrane interface as a coupling region.Molecular neurobiology · 2009Review
- Inositol trisphosphate receptor and ion channel models based on single-channel data.Chaos (Woodbury, N.Y.) · 2009Article
- Identification of Ikr kinetics and drug binding in native myocytes.Annals of biomedical engineering · 2009Article
- Relationship between nucleotide binding and ion channel gating in cystic fibrosis transmembrane conductance regulator.The Journal of physiology · 2009Article
- Thr339-to-serine substitution in rat P2X2 receptor second transmembrane domain causes constitutive opening and indicates a gating role for Lys308.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Activation kinetics of single P2X receptors.Purinergic signalling · 2007Article
- Taking the time to study competitive antagonism.British journal of pharmacology · 2007Review
- Agonist-specific gating of NMDA receptors.Channels (Austin, Tex.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper looks at ion channels as an example of the pharmacologist's stock in trade, the action of an agonist on a receptor to produce a response. Looked at in this way, ion channels have been helpful because they are still the only system which is simple enough for quantitative investigation of transduction mechanisms. A short history is given of attempts to elucidate what happens between the time when agonist first binds, and the time when the channel opens.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.