Trial reportThe pharmacogenomics journal
Interaction between variation in the D2 dopamine receptor (DRD2) and the neuronal calcium sensor-1 (FREQ) genes in predicting response to nicotine replacement therapy for tobacco dependence.
Trial report in The pharmacogenomics journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00326781 (Bio-Behavioral Predictors of the Efficacy of Nicotine Replacement Therapy - Transdisciplinary Tobacco Use Research Center), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Bio-Behavioral Predictors of the Efficacy of Nicotine Replacement Therapy - Transdisciplinary Tobacco Use Research Center (TTURC), Project 2
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- CHRNA3 rs1051730 genotype and short-term smoking cessation.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2011Pooled it
- Influence of a dopamine pathway additive genetic efficacy score on smoking cessation: results from two randomized clinical trials of bupropion.Addiction (Abingdon, England) · 2013Trial
- Association of COMT Val108/158Met genotype with smoking cessation in a nicotine replacement therapy randomized trial.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2007Trial
- The serotonin transporter 5-HTTLPR polymorphism and treatment response to nicotine patch: follow-up of a randomized controlled trial.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2007Trial
- The expression level of Neuronal Calcium Sensor 1 can predict the prognosis of cytogenetically normal AML.The pharmacogenomics journal · 2023Article
- A scoping review of smoking cessation pharmacogenetic studies to advance future research across racial, ethnic, and ancestral populations.Frontiers in genetics · 2023Article
- Nanomolar affinity of EF-hands in neuronal calcium sensor 1 for bivalent cations Pb2+, Mn2+, and Hg2.Metallomics : integrated biometal science · 2022Article
- NCS-1 is a regulator of calcium signaling in health and disease.Biochimica et biophysica acta. Molecular cell research · 2018Review
- A review of pharmacogenetic studies of substance-related disorders.Drug and alcohol dependence · 2015Review
- Pharmacogenetics of nicotine addiction: role of dopamine.Pharmacogenomics · 2014Review
- Neuronal calcium sensor-1 and cocaine addiction: a genetic association study in African-Americans and European Americans.Neuroscience letters · 2012Article
- Biomarkers to optimize the treatment of nicotine dependence.Biomarkers in medicine · 2011Review
- [Pharmacotherapeutic treatment strategies for smoking cessation].Der Nervenarzt · 2011Review
- Black and White adults' perspectives on the genetics of nicotine addiction susceptibility.Addictive behaviors · 2011Article
- Common and unique biological pathways associated with smoking initiation/progression, nicotine dependence, and smoking cessation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Article
- Sex heterogeneity in pharmacogenetic smoking cessation clinical trials.Drug and alcohol dependence · 2009Review
- Genetics of nicotine dependence and pharmacotherapy.Biochemical pharmacology · 2008Review
- Genetics and smoking cessation improving outcomes in smokers at risk.American journal of preventive medicine · 2007Review
- Genetics and smoking behavior.Current psychiatry reports · 2007Review
- Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling.Nature reviews. Neuroscience · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
We have previously demonstrated that a functional dopamine D2 receptor promoter variant (DRD2 -141 Ins/Del) predicts response to nicotine replacement therapy (NRT). The present study extends this finding in the same population of 363 NRT-treated subjects, by examining variation in the gene encoding the neuronal calcium sensor-1 protein (FREQ), which functions to regulate D2 receptor desensitization. The results indicate a statistically significant interaction effect of DRD2-141 and FREQ genotypes on abstinence at the end of the NRT treatment phase; 62% of the smokers with at least one copy of the DRD2 -141 Del allele and two copies of the FREQ rs1054879 A allele were abstinent from smoking, compared to 29-38% abstinence rates for other smokers in the trial. This result suggests that the interaction between variation in the DRD2 and FREQ genes, which both encode components of the D2 dopamine receptor signal transduction pathway, impacts the efficacy of NRT.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.