ArticleThe Journal of experimental medicine2006
G-CSF/SCF reduces inducible arrhythmias in the infarcted heart potentially via increased connexin43 expression and arteriogenesis.
Article in The Journal of experimental medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 112 citations in OpenAlex.
- Granulocyte colony-stimulating factor therapy for stem cell mobilization following anterior wall myocardial infarction: the CAPITAL STEM MI randomized trial.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2014Trial
- Three-dimensional spatial quantitative analysis of cardiac lymphatics in the mouse heart.Microcirculation (New York, N.Y. : 1994) · 2023Article
- Experimental heart failure models in small animals.Heart failure reviews · 2023Review
- Myocardial overexpression of protein phosphatase 2A-B56α improves resistance against ischemia-reperfusion injury.Journal of molecular and cellular cardiology plus · 2023Article
- Transmembrane stem cell factor protein therapeutics enhance revascularization in ischemia without mast cell activation.Nature communications · 2022Article
- Fibroblast-specific IKK-β deficiency ameliorates angiotensin II-induced adverse cardiac remodeling in mice.JCI insight · 2021Article
- Granulocyte colony-stimulating factor attenuates myocardial remodeling and ventricular arrhythmia susceptibility via the JAK2-STAT3 pathway in a rabbit model of coronary microembolization.BMC cardiovascular disorders · 2020Article
- Treatment with mononuclear cell populations improves post-infarction cardiac function but does not reduce arrhythmia susceptibility.PloS one · 2019Article
- Relevance of mouse models of cardiac fibrosis and hypertrophy in cardiac research.Molecular and cellular biochemistry · 2017Review
- The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity.Frontiers in cell and developmental biology · 2015Review
- Hepatocyte growth factor modification enhances the anti-arrhythmic properties of human bone marrow-derived mesenchymal stem cells.PloS one · 2014Article
- Rodent models of heart failure: an updated review.Heart failure reviews · 2013Review
- Stem cell factor gene transfer promotes cardiac repair after myocardial infarction via in situ recruitment and expansion of c-kit+ cells.Circulation research · 2012Article
- Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice.The Journal of clinical investigation · 2012Article
- Proarrhythmia in a non-failing murine model of cardiac-specific Na+/Ca 2+ exchanger overexpression: whole heart and cellular mechanisms.Basic research in cardiology · 2012Article
- Acute effects of granulocyte colony-stimulating factor on early ventricular arrhythmias after coronary occlusion in rats.Journal of pharmacology & pharmacotherapeutics · 2012Article
- Hematopoietic cytokines for cardiac repair: mobilization of bone marrow cells and beyond.Basic research in cardiology · 2011Review
- Article
- Granulocyte colony-stimulating factor for ischemic heart failure: should we use it?Heart failure reviews · 2010Review
- Control of autocrine and paracrine myocardial signals: an emerging therapeutic strategy in heart failure.Heart failure reviews · 2010Review
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Granulocyte colony-stimulating factor (G-CSF), alone or in combination with stem cell factor (SCF), can improve hemodynamic cardiac function after myocardial infarction. Apart from impairing the pump function, myocardial infarction causes an enhanced vulnerability to ventricular arrhythmias. Therefore, we investigated the electrophysiological effects of G-CSF/SCF and the underlying cellular events in a murine infarction model. G-CSF/SCF improved cardiac output after myocardial infarction. Although G-CSF/SCF led to a twofold increased, potentially proarrhythmic homing of bone marrow (BM)-derived cells to the area of infarction, <1% of these cells adopted a cardial phenotype. Inducibility of ventricular tachycardias during programmed stimulation was reduced 5 wk after G-CSF/SCF treatment. G-CSF/SCF increased cardiomyocyte diameter, arteriogenesis, and expression of connexin43 in the border zone of the infarction. An enhanced expression of the G-CSF receptor demonstrated in cardiomyocytes and other cell types of the infarcted myocardium indicates a sensitization of the heart to direct influences of this cytokine. In addition to paracrine effects potentially caused by the increased homing of BM-derived cells, these might contribute to the therapeutic effects of G-CSF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.