ArticleThe American journal of pathology2006
Adrenomedullin is a cross-talk molecule that regulates tumor and mast cell function during human carcinogenesis.
Article in The American journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 75 citations in OpenAlex.
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- Exploring the Molecular Mechanism and Role of Glutathione S-Transferase P in Prostate Cancer.Biomedicines · 2025Article
- Functionally distinct cancer-associated fibroblast subpopulations establish a tumor promoting environment in squamous cell carcinoma.Nature communications · 2023Article
- Peptidergic Systems and Cancer: Focus on Tachykinin and Calcitonin/Calcitonin Gene-Related Peptide Families.Cancers · 2023Review
- Control of myeloid cell functions by nociceptors.Frontiers in immunology · 2023Review
- CCR3-shRNA promotes apoptosis and inhibits chemotaxis and degranulation of mouse mast cells.Experimental and therapeutic medicine · 2020Article
- Targeting Adrenomedullin in Oncology: A Feasible Strategy With Potential as Much More Than an Alternative Anti-Angiogenic Therapy.Frontiers in oncology · 2020Review
- AR facilitates YAP-TEAD interaction with the AM promoter to enhance mast cell infiltration into cutaneous neurofibroma.Scientific reports · 2019Article
- Degranulation of mast cells induced by gastric cancer-derived adrenomedullin prompts gastric cancer progression.Cell death & disease · 2018Article
- Mast cells and angiogenesis in pancreatic ductal adenocarcinoma.Clinical and experimental medicine · 2018Review
- Stromal fibroblasts present in breast carcinomas promote tumor growth and angiogenesis through adrenomedullin secretion.Oncotarget · 2017Article
- Anti-androgen enzalutamide enhances prostate cancer neuroendocrine (NE) differentiation via altering the infiltrated mast cells → androgen receptor (AR) → miRNA32 signals.Molecular oncology · 2015Article
- Expression and clinical significance of focal adhesion kinase and adrenomedullin in epithelial ovarian cancer.Oncology letters · 2015Article
- Article
- Adrenomedullin and tumour microenvironment.Journal of translational medicine · 2014Review
- Transcriptional regulation of adrenomedullin by oncostatin M in human astroglioma cells: implications for tumor invasion and migration.Scientific reports · 2014Article
- Mast Cells in Lung Homeostasis: Beyond Type I Hypersensitivity.Current respiratory medicine reviews · 2014Article
- The impact of the immune system on tumor: angiogenesis and vascular remodeling.Frontiers in oncology · 2014Review
- Elevated expression of adrenomedullin is correlated with prognosis and disease severity in osteosarcoma.Medical oncology (Northwood, London, England) · 2013Article
- RNA interference targeting adrenomedullin induces apoptosis and reduces the growth of human bladder urothelial cell carcinoma.Medical oncology (Northwood, London, England) · 2013Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 2 countries.
Funding
Abstract
We have previously demonstrated that adrenomedullin (AM) plays a critical role as an autocrine/paracrine tumor cell survival factor. We now present evidence that AM is an important regulator of mast cell (MC) function and that this modulation is potentially involved in tumor promotion. AM induced histamine or beta-hexosaminidase release from rat and human MCs through a receptor-independent pathway. AM was chemotactic for human MCs and stimulated mRNA expression of vascular endothelial growth factor, monocyte chemoattractant protein-1, and basic fibroblast growth factor in this cell type. Differentiated but not undifferentiated human MCs responded to hypoxic insult with elevated AM mRNA/protein expression. Using confocal microscopy, we identified AM-producing MCs in tumor infiltrates of human breast and lung cancer patients. In mixed culture assays the AM-producing human MC line HMC-1 augmented both anchorage-dependent and -independent growth of human lung cancer A549 cells, an effect that was suppressed by MC-targeted siRNA AM knockdown. Finally, HMC-1 cells induced in vivo angiogenesis as assessed by directed in vivo angiogenesis assay analysis; neutralizing anti-AM monoclonal antibody blocked this ability. Our collective data suggest a new role for AM as a cross-talk molecule that integrates tumor and MC communication, underlying a unique promotion mechanism of human cancers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.