ArticleThe American journal of pathology2006
Chronic psychological stress in rats induces intestinal sensitization to luminal antigens.
Article in The American journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
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59 citing papers in PubMed, 1 synthesis or guideline pooled it, 159 citations in OpenAlex.
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- Staphylococcal enterotoxin B-derived haptens promote sensitization.Cellular & molecular immunology · 2013Trial
- A human-derived Bacteroides strain attenuates depressive-like behavior in a rat model of social defeat-induced stress.BMC medicine · 2026Article
- Dietary intake ofJournal of genetics · 2022Article
- The Role of Leaky Gut in Functional Dyspepsia.Frontiers in neuroscience · 2022Review
- Enterocytes in Food Hypersensitivity Reactions.Animals : an open access journal from MDPI · 2021Article
- Food hypersensitivity and feline hyperaesthesia syndrome (FHS): A case report.Veterinarni medicina · 2021Article
- The Preventive Role ofJournal of veterinary research · 2021Article
- The Microbiota-Gut-Immune-Glia (MGIG) Axis in Major Depression.Molecular neurobiology · 2020Review
- Evaluation of Invasive Intra-abdominal Candidiasis in Crohn Disease at the Time of Surgery.Annals of coloproctology · 2020Article
- Probiotics Prevents Sensitization to Oral Antigen and Subsequent Increases in Intestinal Tight Junction Permeability in Juvenile-Young Adult Rats.Microorganisms · 2019Article
- Antioxidant Capacity and Behavioral Relevance of a Polyphenolic Extract ofOxidative medicine and cellular longevity · 2019Article
- Opposing Roles of Estradiol and Testosterone on Stress-Induced Visceral Hypersensitivity in Rats.The journal of pain · 2018Article
- Responses of Intestinal Mucosal Barrier Functions of Rats to Simulated Weightlessness.Frontiers in physiology · 2018Article
- Stress-Induced Hyperprolactinemia: Pathophysiology and Clinical Approach.Obstetrics and gynecology international · 2018Review
- "Immune Gate" of Psychopathology-The Role of Gut Derived Immune Activation in Major Psychiatric Disorders.Frontiers in psychiatry · 2018Review
- Vitamin D3 induces vitamin D receptor and HDAC11 binding to relieve the promoter of the tight junction proteins.Oncotarget · 2017Article
- Involvement of CRF2 signaling in enterocyte differentiation.World journal of gastroenterology · 2017Article
- Immune suppression of IgG response against dairy proteins in major depression.BMC psychiatry · 2017Article
- Micro RNA-98 suppresses interleukin-10 in peripheral B cells in patient post-cardio transplantation.Oncotarget · 2017Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is increasing evidence that stress plays a role in the pathophysiology of chronic intestinal disorders, but the mechanisms remain unclear. Previous studies in rats have revealed that stress decreases gut barrier function and allows excessive uptake of luminal material. Here, we investigated whether chronic psychological stress acts to induce sensitization of intestinal tissues to oral antigens. Rats were subjected to 1 hour per day of water avoidance stress or sham stress daily for 10 days, and horseradish peroxidase (HRP) was delivered by gavage on day 5. Studies to determine sensitization were conducted on day 20. All stressed rats developed HRP-specific IgE antibodies, antigen-induced intestinal secretion, and increased numbers of inflammatory cells in gut mucosa. Luminal HRP was absorbed more readily by enterocytes of stressed animals. In addition, stressed rats had increased expression of interleukin-4 and decreased expression of interferon-gamma in gut mucosa, a cytokine profile that is typical of allergic conditions. Treatment of stressed rats with an antagonist to corticotropin-releasing hormone (previously shown to inhibit stress-enhanced gut permeability) eliminated the manifestations of intestinal hypersensitivity. Our results indicate that the presence of oral antigen during chronic psychological stress alters the immune response (to sensitization rather than oral tolerance) and causes subsequent antigen-induced gut pathophysiology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.