ArticleThe American journal of pathology2006
Growth factor midkine is involved in the pathogenesis of diabetic nephropathy.
Article in The American journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 58 citations in OpenAlex.
- Serum Midkine, estimated glomerular filtration rate and chronic kidney disease-related events in elderly women: Perth Longitudinal Study of Aging Women.Scientific reports · 2020Trial
- Integrated bioinformatics analysis uncovers TNFSF10 as a key panoptosis-related gene in diabetic tubular injury.Renal failure · 2026Article
- Neutrophil Extracellular Traps in Diabetic Kidney Disease: Mechanisms of Pathogenesis and Emerging Therapeutic Strategies.Drug design, development and therapy · 2026Review
- Single-Cell RNA Sequencing Reveals Transcriptional Signatures and Cell-Cell Communication in Diabetic Retinopathy.Endocrine, metabolic & immune disorders drug targets · 2024Article
- Midkine promotes kidney injury in diabetic kidney disease by increasing neutrophil extracellular traps formation.Annals of translational medicine · 2022Article
- Midkine-A novel player in cardiovascular diseases.Frontiers in cardiovascular medicine · 2022Review
- Midkine: Utility as a Predictor of Early Diabetic Nephropathy in Children with Type 1 Diabetes MellitusJournal of clinical research in pediatric endocrinology · 2021Article
- Urine and serum midkine levels in an Australian chronic kidney disease clinic population: an observational study.BMJ open · 2017Observational
- Efficacy of urinary midkine as a biomarker in patients with acute kidney injury.Clinical and experimental nephrology · 2017Observational
- Midkine in vitamin D deficiency and its association with anti-Saccharomyces cerevisiae antibodies.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- CD147/basigin reflects renal dysfunction in patients with acute kidney injury.Clinical and experimental nephrology · 2014Article
- PKCδ/midkine pathway drives hypoxia-induced proliferation and differentiation of human lung epithelial cells.American journal of physiology. Cell physiology · 2014Article
- Midkine in nephrogenesis, hypertension and kidney diseases.British journal of pharmacology · 2014Review
- Article
- Benfotiamine increases glucose oxidation and downregulates NADPH oxidase 4 expression in cultured human myotubes exposed to both normal and high glucose concentrations.Genes & nutrition · 2012Article
- Growth factor Midkine is involved in the pathogenesis of renal injury induced by protein overload containing endotoxin.Clinical and experimental nephrology · 2011Article
- Midkine in inflammation.TheScientificWorldJournal · 2011Review
- Midkine: a promising molecule for drug development to treat diseases of the central nervous system.Current pharmaceutical design · 2011Review
- Midkine, a heparin-binding protein, is increased in the diabetic mouse kidney postmenopause.American journal of physiology. Renal physiology · 2011Article
- Midkine inhibitors: application of a simple assay procedure to screening of inhibitory compounds.International archives of medicine · 2010Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic nephropathy is a life-threatening disease associated with diabetes mellitus. Longstanding hyperglycemia induces pathological reactions of glomerular mesangial cells, such as overproduction of extracellular matrix, which finally lead to nephropathy. However, the mechanisms underlying its pathogenesis have not been completely elucidated. Using the Streptozotocin-induced model of diabetes, we report that mice deficient in the growth factor midkine (Mdk-/-) exhibited strikingly milder nephropathy than Mdk+/+ mice, even though both mice showed similar extents of hyperglycemia after Streptozotocin injection. Midkine expression was induced in the glomerular mesangium of Mdk+/+ mice with diabetic nephropathy and in primary cultured mesangial cells exposed to high glucose. Mdk-/- mesangial cells exhibited reduced phosphorylation of protein kinase C and extracellular signal-regulated kinase as well as reduced production of transforming growth factor-beta(1) on high glucose loading. Addition of exogenous midkine restored extracellular signal-regulated kinase phosphorylation in Mdk-/- cells under high glucose conditions, whereas a midkine antisense oligodeoxynucleotide suppressed midkine in Mdk+/+ cells. Therefore, this study identifies midkine as a key molecule in diabetic nephropathy and suggests that midkine accelerates the intracellular signaling network evoked by hyperglycemia in nephropathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.