ArticleAmerican journal of respiratory and critical care medicine2006
Immunoglobulin G levels before and after lung transplantation.
Article in American journal of respiratory and critical care medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02690038 (Feasibility and Safety of Immunoglobulin), which is not on this map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Feasibility and Safety of Immunoglobulin (Ig) Prophylactic Treatment in COPD Patients With Frequent Exacerbations: A Pilot Study
Who cites it
17 citing papers in PubMed, 61 citations in OpenAlex.
- Intravenous immunoglobulin for hypogammaglobulinemia after lung transplantation: a randomized crossover trial.PloS one · 2014Trial
- Acquired hypogammaglobulinemia in HIV-positive subjects after liver transplantation.Transplant infectious disease : an official journal of the Transplantation Society · 2013Trial
- Low immunoglobulin levels affect the course of COPD in hospitalized patients.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023Article
- Article
- Elevated Plasma Immunoglobulin Levels Prior to Heart Transplantation Are Associated with Poor Post-Transplantation Survival.Biology · 2022Article
- Bacterial infections in lung transplantation.Journal of thoracic disease · 2021Review
- Immunoglobulin deficiency as an indicator of disease severity in patients with COVID-19.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Hypogammaglobulinemia and Risk of Exacerbation and Mortality in Patients with COPD.International journal of chronic obstructive pulmonary disease · 2020Article
- Acquired hypogammaglobulinemia and pathogen-specific antibody depletion after solid organ transplantation in human immunodeficiency virus infection: A brief report.Transplant infectious disease : an official journal of the Transplantation Society · 2019Article
- The Expanding Field of Secondary Antibody Deficiency: Causes, Diagnosis, and Management.Frontiers in immunology · 2019Review
- A Prospective Observational Study of Hypogammaglobulinemia in the First Year After Lung Transplantation.Transplantation direct · 2018Article
- Study protocol: a randomized, double-blind, parallel, two-arm, placebo control trial investigating the feasibility and safety of immunoglobulin treatment in COPD patients for prevention of frequent recurrent exacerbations.Pilot and feasibility studies · 2018Article
- Immune function monitoring in lung transplantation using adenosine triphosphate production: time trends and relationship to postoperative infection.Surgery today · 2017Article
- Article
- Clinical immune-monitoring strategies for predicting infection risk in solid organ transplantation.Clinical & translational immunology · 2014Review
- Primary vs. secondary antibody deficiency: clinical features and infection outcomes of immunoglobulin replacement.PloS one · 2014Article
- Incidence, timing, and significance of early hypogammaglobulinemia after intestinal transplantation.Transplantation · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
rationaleThe determinants of immunoglobulin G (IgG) level and the risk of hypogammaglobulinemia (HGG) in patients with severe lung disease before and after lung transplantation are unknown.
objectivesWe aimed to identify predictors of low IgG levels before and after lung transplantation.
methodsWe performed a retrospective cohort study of 40 consecutive lung transplant recipients at our center. Total IgG levels were measured before and serially after transplantation. Mild HGG was defined as IgG levels from 400-699 mg/dl; severe HGG was defined as IgG levels<400 mg/dl. MEASUREMENTS AND MAIN
resultsBefore transplantation, six (15%) patients had mild HGG, and none had severe HGG. Patients with chronic obstructive pulmonary disease had lower IgG levels compared with patients with other diseases (independent of corticosteroid use and age; p=0.001) and an increased risk of mild HGG (p=0.005). The cumulative incidences of mild and severe HGG significantly increased after transplantation (58 and 15%, respectively, both p<0.04 compared with pretransplant prevalences). Lower pretransplant IgG level and treatment with mycophenolate mofetil were associated with lower IgG levels after transplantation (both p<0.05). Only lower pretransplant IgG levels were significantly associated with an increased risk of severe HGG after transplantation (p=0.02).
conclusionsMild HGG is common in patients with severe chronic obstructive pulmonary disease, and the incidences of mild and severe HGG increase significantly early after lung transplantation. Baseline IgG levels and treatment with mycophenolate mofetil affect post-transplant IgG levels.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.